Department of Radiology, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Turkey.
J Clin Ultrasound. 2023 Sep;51(7):1205-1211. doi: 10.1002/jcu.23488. Epub 2023 May 17.
The purpose of this study was to assess the skin involvement in systemic scleroderma patients (SSc) with 2D-Shear Wave Elastography (2D-SWE) and to review the corelation between skin elasticity and pulmonary involvement.
Thirty SSc patients and 30 controls were examined using 2D-SWE. The demographics matched both groups. B-mode ultrasound (US) and 2D-SWE assessed skin thickness and elastography from the ventral side of the right forearm in each subjective. ROC analysis determined optimal group separation cut-off values. A rheumatologist applied mRSS for SSc patients. US, mRSS, and pulmonary involvement correlations were reviewed.
US parameter values (skin thickness, median kPa, median m/s) were higher in the SSc patient group (1.78 ± 0.36 mm, 22.15 ± 16.26, 2.60 ± 0.82, respectively) compared to the control group (1.55 ± 0.2 mm, 7.45 ± 1.84, 1.56 ± 0.2, respectively, p < 0.05). When the optimal cut-off SWE values for separating groups was determined as 10.5 kPa and 1.87 m/s, the sensitivity was 93% and the specificity was 97%. Pearson's correlation analysis showed a strong positive correlation between mRSS and median SWE values (kPa, r = 0.626, p = 0.001; m/s, r = 0.638, p < 0.001). There was no correlation between pulmonary involvement of SSc patients with mRSS and US parameters.
2D-SWE is a promising non-invasive method to evaluate skin involvement in SSc patient group. For pulmonary involvement we need more data with bigger patient groups.
本研究旨在使用二维剪切波弹性成像（2D-SWE）评估系统性硬皮病（SSc）患者的皮肤受累情况，并探讨皮肤弹性与肺受累之间的相关性。
对 30 例 SSc 患者和 30 例对照者进行 2D-SWE 检查。两组患者的人口统计学特征相匹配。在每个患者的右侧前臂腹侧使用 B 型超声（US）和 2D-SWE 评估皮肤厚度和弹性。ROC 分析确定最佳分组分离的截断值。一名风湿病学家对 SSc 患者应用 mRSS。对 US、mRSS 和肺受累的相关性进行了评估。
与对照组（1.55±0.2mm，7.45±1.84kPa，1.56±0.2m/s）相比，SSc 患者组的 US 参数值（皮肤厚度、中位数 kPa、中位数 m/s）更高（1.78±0.36mm，22.15±16.26kPa，2.60±0.82m/s，p<0.05）。当确定区分两组的最佳 SWE 值截断值为 10.5kPa 和 1.87m/s 时，灵敏度为 93%，特异性为 97%。Pearson 相关分析显示，mRSS 与中位 SWE 值（kPa，r=0.626，p=0.001；m/s，r=0.638，p<0.001）之间存在强正相关。SSc 患者的 mRSS 和 US 参数与肺受累之间无相关性。
2D-SWE 是评估 SSc 患者皮肤受累的一种很有前途的非侵入性方法。对于肺受累，我们需要更多的大患者组数据。
