McCaigue M D, Halton D W, Hopkins C A
Exp Parasitol. 1986 Aug;62(1):51-60. doi: 10.1016/0014-4894(86)90007-x.
Ultrastructural studies, including stereological analyses of micrographs, have been made of five-worm primary infections of Hymenolepis diminuta from C57 mice to determine whether the immune destrobilation/rejection process was accompanied by significant changes in the fine structure of the scolex tegument. Destrobilation/rejection of worms occurred from Days 9-12 after infection. For the first 5 days after infection, the scolex tegument showed no detectable differences in ultrastructure compared with that of "control" worms from either Wistar rats or immunosuppressed C57 mice. By Day 6, large lipid deposits were observed in the tegument and associated musculature of worms from untreated C57 mice. Further, worms recovered from Days 6-8 after infection also showed increased activity of the Golgi apparatus, GER, and mitochondria of the tegument, resulting in increased numbers of discoidal secretory bodies. Concomitant with destrobilation/rejection from Day 9 was a drop in the number of secretory bodies, an increase in autophagic activity throughout the tegument, and a blistering of the tegument surface plasma membrane. The possible functional significance of the results is discussed in relation to host immunity.
已对来自C57小鼠的微小膜壳绦虫五虫原发性感染进行了超微结构研究，包括对显微照片的体视学分析，以确定免疫性虫体破坏/排斥过程是否伴随着头节皮层精细结构的显著变化。感染后第9至12天出现虫体破坏/排斥现象。在感染后的前5天，与来自Wistar大鼠或免疫抑制C57小鼠的“对照”虫体相比，头节皮层的超微结构没有可检测到的差异。到第6天，在未处理的C57小鼠的虫体皮层和相关肌肉组织中观察到大量脂质沉积。此外，感染后第6至8天回收的虫体还显示皮层的高尔基体、GER和线粒体活性增加，导致盘状分泌体数量增加。从第9天开始出现虫体破坏/排斥的同时，分泌体数量下降，整个皮层的自噬活性增加，皮层表面质膜出现水泡。结合宿主免疫讨论了这些结果可能的功能意义。
