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德班沙门氏菌脑膜炎:病例报告和基因组学研究。

Salmonella Durban meningitis: case report and genomics study.

机构信息

Department of Pediatrics, CHC, Clinique MontLégia, Liège, Belgium.

University of Liège (ULiège), 5Th Master in Pediatrics, Liège, Belgium.

出版信息

BMC Infect Dis. 2023 May 20;23(1):338. doi: 10.1186/s12879-023-08308-7.

Abstract

BACKGROUND

Bacterial meningitis caused by non-typhoid Salmonella can be a fatal condition which is more common in low and middle-income countries.

CASE PRESENTATION

We report the case of a Salmonella meningitis in a Belgian six-month old male infant. The first clinical examination was reassuring, but after a few hours, his general state deteriorated. A blood test and a lumbar puncture were therefore performed. The cerebrospinal fluid analysis was compatible with a bacterial meningitis which was later identified by the NRC (National Reference Center) as Salmonella enterica serovar Durban.

CONCLUSIONS

In this paper, we present the clinical presentation, genomic typing, and probable sources of infection for an unusually rare serovar of Salmonella. Through an extended genomic analysis, we established its relationship to historical cases with links to Guinea.

摘要

背景

由非伤寒沙门氏菌引起的细菌性脑膜炎可能是一种致命的疾病,在中低收入国家更为常见。

病例介绍

我们报告了一例发生在一名比利时六个月大男婴身上的沙门氏菌脑膜炎病例。第一次临床检查结果令人安心,但几小时后,他的一般状况恶化。因此进行了血液检查和腰椎穿刺。脑脊液分析符合细菌性脑膜炎,后来 NRC(国家参考中心)鉴定为都柏林沙门氏菌肠炎亚种。

结论

本文介绍了一例不同寻常的罕见沙门氏菌血清型的临床表现、基因组分型和可能的感染源。通过扩展的基因组分析,我们确定了它与几内亚有关的历史病例的关系。

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