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重复经颅磁刺激治疗阿尔茨海默病患者伴行为和心理症状的痴呆:一例报告。

The repetitive transcranial magnetic stimulation in Alzheimer's disease patients with behavioral and psychological symptoms of dementia: a case report.

机构信息

University of South China, Heng Yang, 421001, China.

Neurology Department, The First Hospital Of Chang Sha, Chang Sha City, 410000, China.

出版信息

BMC Psychiatry. 2023 May 23;23(1):354. doi: 10.1186/s12888-023-04864-z.

Abstract

BACKGROUND

Repetitive transcranial magnetic stimulation is a noninvasive intervention, can significantly reduce behavioral and psychological symptoms and cognitive impairment in AD patients. Only few cases have been reported the adverse reactions after the treatment. This report described the different adverse reactions after repetitive transcranial magnetic stimulation with different parameters.

PATIENT PRESENTATION

This article reports a patient with dementia complicated with mental behavior disorder who was treated with repetitive transcranial magnetic stimulation (rTMS) in spite of poor drug response. First, 1 Hz rTMS was initiated. After 1 month, the patient showed improved symptoms of mental behavior, decreased cognitive function and prolonged sleep duration. After switched to 10 Hz rTMS, the patient's cognitive function and mental behavior abnormalities improved, and the sleep time returned to normal. However, epilepsy occurred after one session and was changed to 0.8 Hz rTMS treatment. The patient's symptoms improved and did not have seizure.

CONCLUSION

Repetitive transcranial magnetic stimulation has a positive effect on cognitive function and Behavioral And Psychological Symptoms Of Dementia, and adverse reactions are inevitable. Playing personalized treatment according to the patients can reduce occurrence of adverse reactions.

摘要

背景

重复经颅磁刺激是一种非侵入性干预措施,可显著减少 AD 患者的行为和心理症状及认知障碍。仅少数病例报告了治疗后的不良反应。本报告描述了不同参数的重复经颅磁刺激后的不同不良反应。

患者表现

本文报道了一例痴呆合并精神行为障碍的患者,尽管药物反应不佳,但仍接受重复经颅磁刺激(rTMS)治疗。首先,给予 1Hz rTMS。1 个月后,患者的精神行为症状改善,认知功能下降,睡眠时间延长。切换到 10Hz rTMS 后,患者的认知功能和精神行为异常改善,睡眠时间恢复正常。然而,一次治疗后出现癫痫,改为 0.8Hz rTMS 治疗。患者症状改善,无癫痫发作。

结论

重复经颅磁刺激对认知功能和痴呆的行为和心理症状有积极作用,不良反应不可避免。根据患者情况进行个体化治疗可以减少不良反应的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2d/10207599/9724575fe31d/12888_2023_4864_Fig1_HTML.jpg

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