氟代脱氧葡萄糖脑正电子发射断层显像/磁共振成像在肌萎缩侧索硬化-额颞叶谱系障碍（ALS-FTSD）中的应用
F-FDG Brain PET/MRI in Amyotrophic Lateral Sclerosis- Frontotemporal Spectrum Disorder (ALS-FTSD).
作者信息
Mashriqi Faizullah, Mishra Bibhuti B, Giliberto Luca, Franceschi Ana M
机构信息
Neuroradiology Division, Department of Radiology, Northwell Health/Donald and Barbara Zucker School of Medicine, Lenox Hill Hospital, New York, United States.
Department of Neurology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, The Feinstein Institutes for Medical Research. Manhasset, New York, United States.
出版信息
World J Nucl Med. 2023 May 1;22(2):135-139. doi: 10.1055/s-0043-1760762. eCollection 2023 Jun.
Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving both upper and lower motor neurons. Interestingly, 15 to 41% of patients with ALS have concomitant frontotemporal dementia (FTD). Approximately, 50% of patients with ALS can copresent with a broader set of neuropsychological pathologies that do not meet FTD diagnostic criteria. This association resulted in revised and expanded criteria establishing the ALS-frontotemporal spectrum disorder (FTSD). In this case report, we review background information, epidemiology, pathophysiology, and structural and molecular imaging features of ALS-FTSD.
肌萎缩侧索硬化症（ALS）是一种致命的、进行性的神经退行性疾病，累及上下运动神经元。有趣的是，15%至41%的ALS患者同时患有额颞叶痴呆（FTD）。大约50%的ALS患者可能同时出现一系列更广泛的神经心理病理学症状，但不符合FTD的诊断标准。这种关联导致了修订和扩展后的标准，确立了ALS-额颞叶谱系障碍（FTSD）。在本病例报告中，我们回顾了ALS-FTSD的背景信息、流行病学、病理生理学以及结构和分子影像学特征。
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