Jeele Mohamed Osman Omar, Adan Abdisamad M
Department of Internal Medicine, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia.
Ann Med Surg (Lond). 2023 Apr 6;85(5):2112-2114. doi: 10.1097/MS9.0000000000000482. eCollection 2023 May.
Nephrotic syndrome (NS) is a clinical disorder characterized by significant proteinuria, hypoalbuminemia, hyperlipidemia, edema, and other complications. Urinary loss of clotting inhibitors, zymogens, and plasminogen; increased hepatic synthesis of fibrinogen and lipoproteins, and hemoconcentration due to fluid loss are some of the factors which predispose NS patients to hypercoagulable states like portal vein thrombosis.
In the presenting case report, we described a 21-year-old woman with no history of NS and a hypercoagulable state who presented to our emergency department with severe generalized abdominal pain and lower limb edema. She was subsequently diagnosed with NS complicated with portal vein thrombosis and was admitted to our internal medicine unit. After 2 weeks of treatment, the patient was discharged in good health.
Additional evaluation for newly onset NS with venous thrombosis should be needed in the presence of severe abdominal pain and lower limb edema even in a patient without a previous history of NS.
肾病综合征（NS）是一种临床病症，其特征为大量蛋白尿、低白蛋白血症、高脂血症、水肿及其他并发症。凝血抑制剂、酶原和纤溶酶原的尿中丢失；纤维蛋白原和脂蛋白的肝脏合成增加，以及因液体丢失导致的血液浓缩，是使NS患者易发生门静脉血栓形成等高凝状态的部分因素。
在本病例报告中，我们描述了一名21岁无NS病史和高凝状态的女性，她因严重的全身性腹痛和下肢水肿就诊于我们的急诊科。她随后被诊断为NS并发门静脉血栓形成，并入住我们的内科病房。经过2周的治疗，患者康复出院。
即使是既往无NS病史的患者，若出现严重腹痛和下肢水肿，也应对新发NS合并静脉血栓形成进行进一步评估。
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