Bahouh Choukri, Arhoun El Haddad Inass, Elmouhib Amine, Laaribi Ilyass, El Adak Hanane, Hattab Oumaima, El Ouafi Nouha, Bkiyar Houssam, Housni Brahim
Department of Intensive Care Unit, Mohammed VI University Hospital.
Faculty of Medicine and Pharmacy, Mohammed First University.
Ann Med Surg (Lond). 2023 Apr 14;85(5):2186-2189. doi: 10.1097/MS9.0000000000000636. eCollection 2023 May.
Autonomic dysfunction is a prevalent symptom of Guillain-Barré syndrome (GBS); cardiovascular involvement in this scenario has been mentioned infrequently in the literature.
A 65-year-old man with GBS presented with reversible left ventricular systolic failure. On first presentation, our patient had no history or indications of heart malfunction. During the clinical manifestation of his autonomic dysfunction, he had electrocardiographic alterations, modestly increased cardiac enzymes, significant left ventricular systolic dysfunction, and segmental wall motion irregularity. Once the initial episode was over, these anomalies and his symptoms resolved quickly.
We believe the reversible left ventricular dysfunction was caused by the toxic impact of elevated catecholamines as well as transiently injured sympathetic nerve endings in the myocardium, which was apparently caused by GBS. We recommend that echocardiography be performed in patients who exhibit clinical signs of autonomic dysfunction, particularly if they are associated with abnormal electrocardiographic findings, cardiac enzyme elevation, or hemodynamic instability, so that appropriate medical therapy can be instituted as soon as possible.
GBS is a not a very rare situation in our context. Thus, doctors are supposed to know the life-threatening complications such as neurogenic stunned myocardium and be prepared to dodge it.
自主神经功能障碍是吉兰-巴雷综合征(GBS)的常见症状;文献中很少提及这种情况下的心血管受累情况。
一名65岁的GBS男性患者出现可逆性左心室收缩功能衰竭。首次就诊时,我们的患者没有心脏功能障碍的病史或迹象。在其自主神经功能障碍的临床表现期间,他出现了心电图改变、心肌酶轻度升高、明显的左心室收缩功能障碍以及节段性室壁运动异常。一旦初始发作结束,这些异常和他的症状迅速缓解。
我们认为可逆性左心室功能障碍是由儿茶酚胺升高的毒性作用以及心肌中交感神经末梢的短暂损伤引起的,这显然是由GBS导致的。我们建议对出现自主神经功能障碍临床体征的患者进行超声心动图检查,特别是如果这些体征与心电图异常、心肌酶升高或血流动力学不稳定相关,以便能够尽快开始适当的药物治疗。
在我们的背景下,GBS并非非常罕见的情况。因此,医生应该了解诸如神经源性心肌顿抑等危及生命的并发症,并准备好避免它。