丙戊酸盐所致代谢综合征

Valproate-Induced Metabolic Syndrome.

作者信息

Shnayder Natalia A, Grechkina Violetta V, Trefilova Vera V, Efremov Ilya S, Dontceva Evgenia A, Narodova Ekaterina A, Petrova Marina M, Soloveva Irina A, Tepnadze Liia E, Reznichenko Polina A, Al-Zamil Mustafa, Altynbekova Gulnara I, Strelnik Anna I, Nasyrova Regina F

机构信息

Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia.

Shared Core Facilities "Molecular and Cell Technologies", V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.

出版信息

Biomedicines. 2023 May 22;11(5):1499. doi: 10.3390/biomedicines11051499.

DOI:10.3390/biomedicines11051499

PMID:37239168

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10216246/

Abstract

Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis. In this review, we consider the results of studies of blood (serum and plasma) and the urinary biomarkers of VPA-MetS. These metabolic biomarkers may provide the key to the development of a new multidisciplinary personalized strategy for the prevention and diagnosis of VPA-MetS in patients with neurological diseases, psychiatric disorders, and addiction diseases.

摘要

丙戊酸（VPA）及其盐类（钠盐、钙盐、镁盐和乳清酸盐）是广泛应用于神经科和精神科的精神药物。长期使用VPA会增加发生药物不良反应（ADR）的风险，其中代谢综合征（MetS）起着特殊作用。MetS属于一组代谢状况，如腹型肥胖、高血压、高血糖、高血清甘油三酯和低血清高密度脂蛋白。丙戊酸盐诱导的代谢综合征（VPA-MetS）是一种常见的ADR，需要采用最新的多学科方法进行预防和诊断。在本综述中，我们考虑了关于VPA-MetS血液（血清和血浆）及尿液生物标志物的研究结果。这些代谢生物标志物可能为制定针对神经疾病、精神障碍和成瘾性疾病患者预防和诊断VPA-MetS的新型多学科个性化策略提供关键依据。