Department of Physiology, Faculty of Health Sciences-Ceuta, University of Granada, 51001 Ceuta, Spain.
Servicio Andaluz de Salud, 18014 Granada, Spain.
Int J Mol Sci. 2023 May 12;24(10):8675. doi: 10.3390/ijms24108675.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown etiology. Many metabolic alterations occur during ALS progress and can be used as a method of pre-diagnostic and early diagnosis. Dyslipidemia is one of the physiological changes observed in numerous ALS patients. The aim of this study is to analyze the possible relationship between the rate of disease progression (functional rating scale (ALS-FRS)) and the plasma lipid levels at the early stage of ALS. A systematic review was carried out in July 2022. The search equation was "Triglycerides AND amyotrophic lateral sclerosis" and its variants. Four meta-analyses were performed. Four studies were included in the meta-analysis. No significant differences were observed between the lipid levels (total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol) and the ALS-FRS score at the onset of the disease. Although the number of studies included in this research was low, the results of this meta-analytic study suggest that there is no clear relationship between the symptoms observed in ALS patients and the plasma lipid levels. An increase in research, as well as an expansion of the geographical area, would be of interest.
肌萎缩侧索硬化症（ALS）是一种病因不明的致命神经退行性疾病。在 ALS 进展过程中会发生许多代谢改变，可作为预诊断和早期诊断的方法。血脂异常是许多 ALS 患者观察到的生理变化之一。本研究旨在分析疾病进展率（功能评定量表（ALS-FRS））与 ALS 早期阶段血浆脂质水平之间的可能关系。在 2022 年 7 月进行了系统评价。搜索方程为“甘油三酯和肌萎缩侧索硬化症”及其变体。进行了四项荟萃分析。四项研究被纳入荟萃分析。在疾病发作时，脂质水平（总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇）与 ALS-FRS 评分之间未观察到显著差异。尽管这项研究纳入的研究数量较少，但这项荟萃分析研究的结果表明，ALS 患者观察到的症状与血浆脂质水平之间没有明确的关系。增加研究以及扩大地理区域将是有益的。
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