Liu Wei-Ting, Wang Han-Tang, Yeh Yi-Hsuan, Wong Tak-Wah
Department of Dermatology, Cancer Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
School of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Pharmaceutics. 2023 Apr 24;15(5):1328. doi: 10.3390/pharmaceutics15051328.
Primary cutaneous lymphomas are rare non-Hodgkin lymphomas consisting of heterogeneous disease entities. Photodynamic therapy (PDT) utilizing photosensitizers irradiated with a specific wavelength of light in the presence of oxygen exerts promising anti-tumor effects on non-melanoma skin cancer, yet its application in primary cutaneous lymphomas remains less recognized. Despite many in vitro data showing PDT could effectively kill lymphoma cells, clinical evidence of PDT against primary cutaneous lymphomas is limited. Recently, a phase 3 "FLASH" randomized clinical trial demonstrated the efficacy of topical hypericin PDT for early-stage cutaneous T-cell lymphoma. An update on recent advances of photodynamic therapy in primary cutaneous lymphomas is provided.
原发性皮肤淋巴瘤是罕见的非霍奇金淋巴瘤，由多种不同的疾病实体组成。光动力疗法（PDT）利用光敏剂在氧气存在的情况下接受特定波长的光照，对非黑素瘤皮肤癌具有显著的抗肿瘤作用，但其在原发性皮肤淋巴瘤中的应用仍未得到充分认识。尽管许多体外数据表明PDT可有效杀死淋巴瘤细胞，但PDT治疗原发性皮肤淋巴瘤的临床证据有限。最近，一项3期“FLASH”随机临床试验证明了局部金丝桃素光动力疗法对早期皮肤T细胞淋巴瘤的疗效。本文提供了光动力疗法在原发性皮肤淋巴瘤中最新进展的综述。
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