Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA.
Calcif Tissue Int. 2023 Jul;113(1):83-95. doi: 10.1007/s00223-023-01095-y. Epub 2023 May 27.
The bone marrow microenvironment contains a diverse array of cell types under extensive regulatory control and provides for a novel and complex mechanism for bone regulation. Megakaryocytes (MKs) are one such cell type that potentially acts as a master regulator of the bone marrow microenvironment due to its effects on hematopoiesis, osteoblastogenesis, and osteoclastogenesis. While several of these processes are induced/inhibited through MK secreted factors, others are primarily regulated by direct cell-cell contact. Notably, the regulatory effects that MKs exert on these different cell populations has been found to change with aging and disease states. Overall, MKs are a critical component of the bone marrow that should be considered when examining regulation of the skeletal microenvironment. An increased understanding of the role of MKs in these physiological processes may provide insight into novel therapies that can be used to target specific pathways important in hematopoietic and skeletal disorders.
骨髓微环境包含多种细胞类型，这些细胞受到广泛的调控，并提供了一种新颖而复杂的骨骼调节机制。巨核细胞（MK）是这样一种细胞类型，由于其对造血、成骨细胞生成和破骨细胞生成的影响，MK 可能充当骨髓微环境的主调控因子。虽然这些过程中的几个过程是通过 MK 分泌的因子诱导/抑制的，但其他过程主要通过直接的细胞-细胞接触来调节。值得注意的是，MK 对这些不同细胞群的调节作用会随着衰老和疾病状态而改变。总体而言，MK 是骨髓的关键组成部分，在研究骨骼微环境的调节时应考虑到这一点。增加对 MK 在这些生理过程中的作用的理解，可能为针对造血和骨骼疾病中重要的特定途径的新型治疗方法提供启示。
