通过基于串联质谱的合理分子网络策略探索天然产物中的二聚化多样性。
Exploring Diversity through Dimerization in Natural Products by a Rational Tandem Mass-Based Molecular Network Strategy.
机构信息
State Key Laboratory of Cellular Stress Biology, State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
出版信息
Org Lett. 2023 Jun 9;25(22):4016-4021. doi: 10.1021/acs.orglett.3c01038. Epub 2023 May 30.
The step- and atom-efficient dimerization strategy is frequently used in nature to build structural complexity and diversity. We propose the rationale and structural features of the versatile monomers that are responsible for "diversity through dimerization". Using 5-FAM-maleimide combined with a UHPLC-MS/MS-FBMN workflow, we successfully identified a diverse set of dimeric natural products from fungus F01315, in which all four complex 4'5-ring scaffolds are derived from one monomeric epoxyquinol and endowed with functional diversity.
逐步和原子经济的二聚策略在自然界中被广泛用于构建结构复杂性和多样性。我们提出了负责“通过二聚化实现多样性”的多功能单体的原理和结构特征。使用 5-FAM-马来酰亚胺与 UHPLC-MS/MS-FBMN 工作流程相结合，我们成功地从真菌 F01315 中鉴定出了一组多样化的二聚体天然产物，其中所有四个复杂的 4'5-环支架均来自于一个单体环氧醌，并具有功能多样性。
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