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H-联萘酚催化不对称方法的最新进展

Recent Advancement in H-BINOL Catalyzed Asymmetric Methodologies.

作者信息

Kshatriya Rajpratap

机构信息

School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences, University of Mumbai, Kalina, Santacruz (E), Mumbai, Maharashtra 400098,India.

出版信息

ACS Omega. 2023 May 11;8(20):17381-17406. doi: 10.1021/acsomega.2c05535. eCollection 2023 May 23.

DOI:10.1021/acsomega.2c05535
PMID:37251114
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10210047/
Abstract

H-BINOL, a partially reduced form of BINOL, is widely employed in a broad array of organocatalyzed asymmetric methodologies. Over the last 25 years, asymmetric organocatalysis has witnessed an incredible improvement, and an advancement still continues to get a single enantio-enriched product. The broad-spectrum applications of H-BINOL organocatalyst in C-C bond formation, C-heteroatom bond construction, name reactions, pericyclic reactions, and one pot and multicomponent reaction are attracting the attention of researchers. A diversified unique H-BINOL-based catalyst has been synthesized and screened for catalytic activity. In this Review we frame out the H-BINOL catalyzed novel discoveries from the last two decades.

摘要

H-BINOL是联萘酚（BINOL）的部分还原形式，广泛应用于众多有机催化的不对称方法中。在过去25年里，不对称有机催化取得了惊人的进展，并且仍在不断进步以获得单一对映体富集产物。H-BINOL有机催化剂在碳-碳键形成、碳-杂原子键构建、命名反应、周环反应以及一锅法和多组分反应中的广泛应用正吸引着研究人员的关注。已合成并筛选了多种独特的基于H-BINOL的催化剂以考察其催化活性。在本综述中，我们梳理了过去二十年中H-BINOL催化的新发现。

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