Lozano-Vicario Lucía, García-Hermoso Antonio, Cedeno-Veloz Bernardo Abel, Fernández-Irigoyen Joaquín, Santamaría Enrique, Romero-Ortuno Román, Zambom-Ferraresi Fabricio, Sáez de Asteasu Mikel L, Muñoz-Vázquez Ángel Javier, Izquierdo Mikel, Martínez-Velilla Nicolás
Geriatric Unit, Hospital Universitario de Navarra (HUN), Pamplona, Spain.
Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
Front Aging Neurosci. 2023 May 12;15:1174644. doi: 10.3389/fnagi.2023.1174644. eCollection 2023.
Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus databases up to August 2021. A total of 32 studies were included. Only 6 studies were eligible for the meta-analysis, pooled results showed a significant increase in some serum biomarkers (C-reactive protein [CRP], tumour necrosis factor alpha [TNF-α] and interleukin-6 [IL-6]) among patients with delirium (odds ratio = 1.88, 95% CI 1.01 to 1.637; I2 = 76.75%). Although current evidence does not favour the use of any particular biomarker, serum CRP, TNF-, and IL-6 were the most consistent biomarkers of delirium in older patients.
谵妄是一种神经精神综合征，与老年患者发病率和死亡率的增加相关。本研究的目的是回顾老年患者谵妄的预测生物标志物，以深入了解该综合征的病理生理学，并为未来的研究提供指导。两名作者独立且系统地检索了截至2021年8月的MEDLINE、Embase、Cochrane图书馆、科学网和Scopus数据库。共纳入32项研究。只有6项研究符合荟萃分析的条件，汇总结果显示，谵妄患者的一些血清生物标志物（C反应蛋白[CRP]、肿瘤坏死因子α[TNF-α]和白细胞介素-6[IL-6]）显著增加（优势比=1.88，95%CI 1.01至1.637；I2=76.75%）。尽管目前的证据不支持使用任何特定的生物标志物，但血清CRP、TNF-和IL-6是老年患者谵妄最一致的生物标志物。
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