Boldyrev I A, Shendrikov V P, Vostrova A G, Vodovozova E L
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia.
Russ J Bioorg Chem. 2023;49(2):412-415. doi: 10.1134/S1068162023020061. Epub 2023 May 19.
The ionizable lipid ALC-0315, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), is a component of the lipid matrix of the prophylactic SARS-CoV-2 mRNA vaccine produced by Pfizer/BioNTech. This lipid ensures efficient vaccine assembly, protects the mRNA from premature degradation, and promotes the release of the nucleic acid into the cytoplasm for its further processing after endocytosis. The present work describes a simple and economical method for the synthesis of the ALC-0315 lipid, which can be taken advantage of in mRNA vaccine production.
可电离脂质ALC-0315，即((4-羟丁基)氮杂二亚基)双(己烷-6,1-二亚基)双(2-己基癸酸酯)，是辉瑞/生物新技术公司生产的预防性SARS-CoV-2 mRNA疫苗脂质基质的一种成分。这种脂质可确保疫苗有效组装，保护mRNA不被过早降解，并促进核酸在胞吞作用后释放到细胞质中以便进一步加工。本研究描述了一种合成ALC-0315脂质的简单且经济的方法，该方法可用于mRNA疫苗生产。
