文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

自然杀伤细胞通过免疫调节增强顺铂的抗肿瘤活性，并改善顺铂引起的副作用。

Natural killer cells strengthen antitumor activity of cisplatin by immunomodulation and ameliorate cisplatin-induced side effects.

机构信息

Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Department of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

出版信息

Int Urol Nephrol. 2023 Aug;55(8):1957-1970. doi: 10.1007/s11255-023-03650-w. Epub 2023 May 30.

DOI:10.1007/s11255-023-03650-w
PMID:37253929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10329593/
Abstract

PURPOSE: Cisplatin-based chemotherapy is now an important treatment for improving bladder cancer prognosis. However, challenges in clinical treatment remain due to the numerous side effects of chemotherapy. Natural killer (NK) cells regulate certain immune responses and play a significant role in tumor surveillance and control. The efficacy of NK cells combined with cisplatin for chemoimmunotherapy in bladder cancer remains poorly understood. METHODS: In this study, we established an MB49 tumor-bearing mouse model, tumor growth was measured in a control group and in groups treated with cisplatin, NK cells or both. Organ indices, biochemical indicators of blood serum, and expression of apoptotic proteins were used to assess the extent of organ damage. ELISA and immunohistochemistry were used to analyze the levels of immune cells and cytokine expression in serum, spleen, and tumor tissue. RESULTS: NK cells combined with cisplatin exhibited better antitumor activity. NK cells also alleviated the organ damage caused by cisplatin and improved the survival rate. Treatment with NK cells increased the expression of IL-2 and IFN-γ as well as the number of CD4 + T cells. Additionally, cisplatin increased the expression of natural killer group 2, member D (NKG2D) ligands thus activating NK cells to kill tumor cells. CONCLUSION: NK cells could alleviate the side effects of cisplatin treatment and enhance antitumor activity. The combination of NK cells and cisplatin thus provides a promising option for chemoimmunotherapy for bladder cancer.

摘要

目的：顺铂为基础的化疗目前是改善膀胱癌预后的重要治疗手段。然而，由于化疗的许多副作用，临床治疗仍存在挑战。自然杀伤 (NK) 细胞调节某些免疫反应，在肿瘤监测和控制中发挥重要作用。NK 细胞联合顺铂用于膀胱癌的化免疫治疗的疗效仍知之甚少。

方法：本研究建立了 MB49 荷瘤小鼠模型，在对照组和用顺铂、NK 细胞或两者治疗的组中测量肿瘤生长。用器官指数、血清生化指标和凋亡蛋白表达来评估器官损伤程度。ELISA 和免疫组化用于分析血清、脾脏和肿瘤组织中免疫细胞和细胞因子表达水平。

结果：NK 细胞联合顺铂表现出更好的抗肿瘤活性。NK 细胞还减轻了顺铂引起的器官损伤，提高了存活率。NK 细胞治疗增加了白细胞介素 2 和干扰素-γ的表达以及 CD4+T 细胞的数量。此外，顺铂增加了自然杀伤组 2，成员 D (NKG2D) 配体的表达，从而激活 NK 细胞杀死肿瘤细胞。

结论：NK 细胞可以减轻顺铂治疗的副作用，并增强抗肿瘤活性。因此，NK 细胞与顺铂的联合为膀胱癌的化免疫治疗提供了一种有前途的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/a45028c1b9b9/11255_2023_3650_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/226ea2fff3f1/11255_2023_3650_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/af5a2b293e79/11255_2023_3650_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/682700917892/11255_2023_3650_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/35cd1a0d8a22/11255_2023_3650_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/495bd111bb87/11255_2023_3650_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/a45028c1b9b9/11255_2023_3650_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/226ea2fff3f1/11255_2023_3650_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/af5a2b293e79/11255_2023_3650_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/682700917892/11255_2023_3650_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/35cd1a0d8a22/11255_2023_3650_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/495bd111bb87/11255_2023_3650_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf52/10329593/a45028c1b9b9/11255_2023_3650_Fig6_HTML.jpg

相似文献

[1]
Natural killer cells strengthen antitumor activity of cisplatin by immunomodulation and ameliorate cisplatin-induced side effects.

Int Urol Nephrol. 2023-8

[2]
Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells.

BMC Med. 2016-10-21

[3]
Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity.

J Immunother Cancer. 2021-10

[4]
Cisplatin enhances NK cells immunotherapy efficacy to suppress HCC progression via altering the androgen receptor (AR)-ULBP2 signals.

Cancer Lett. 2016-4-1

[5]
Electroporation driven delivery of both an IL-12 expressing plasmid and cisplatin synergizes to inhibit B16 melanoma tumor growth through an NK cell mediated tumor killing mechanism.

Hum Vaccin Immunother. 2012-11-1

[6]
Cetuximab therapy in head and neck cancer: immune modulation with interleukin-12 and other natural killer cell-activating cytokines.

Surgery. 2012-7-6

[7]
Activated NK cells reprogram MDSCs via NKG2D-NKG2DL and IFN-γ to modulate antitumor T-cell response after cryo-thermal therapy.

J Immunother Cancer. 2022-12

[8]
Interleukin 2 gene transfer prevents NKG2D suppression and enhances antitumor efficacy in combination with cisplatin for head and neck squamous cell cancer.

Cancer Res. 2002-7-15

[9]
Inhibition of EZH2 induces NK cell-mediated differentiation and death in muscle-invasive bladder cancer.

Cell Death Differ. 2019-1-28

[10]
Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice.

BMC Cancer. 2009-3-17

本文引用的文献

[1]
Ameliorative impacts of polymeric and metallic nanoparticles on cisplatin-induced nephrotoxicity: a 2011-2022 review.

J Nanobiotechnology. 2022-12-1

[2]
Genetic Engineering and Enrichment of Human NK Cells for CAR-Enhanced Immunotherapy of Hematological Malignancies.

Front Immunol. 2022

[3]
Synergistic Tumor Cytolysis by NK Cells in Combination With a Pan-HDAC Inhibitor, Panobinostat.

Front Immunol. 2021

[4]
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy.

Signal Transduct Target Ther. 2020-10-29

[5]
Global Trends of Bladder Cancer Incidence and Mortality, and Their Associations with Tobacco Use and Gross Domestic Product Per Capita.

Eur Urol. 2020-12

[6]
Exploring the NK cell platform for cancer immunotherapy.

Nat Rev Clin Oncol. 2021-2

[7]
Lentinan Inhibits Tumor Progression by Immunomodulation in a Mouse Model of Bladder Cancer.

Integr Cancer Ther. 2020

[8]
Natural Killer Cells: Tumor Surveillance and Signaling.

Cancers (Basel). 2020-4-11

[9]
Recalling the Biological Significance of Immune Checkpoints on NK Cells: A Chance to Overcome LAG3, PD1, and CTLA4 Inhibitory Pathways by Adoptive NK Cell Transfer?

Front Immunol. 2020-1-9

[10]
Development of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells.

Br J Cancer. 2020-3

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索