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从新冠肺炎危重症中康复:ISARIC4C CCP-UK队列研究和RECOVER试验的二次分析

Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial.

作者信息

Pauley Ellen, Drake Thomas M, Griffith David M, Sigfrid Louise, Lone Nazir I, Harrison Ewen M, Baillie J Kenneth, Scott Janet T, Walsh Timothy S, Semple Malcolm G, Docherty Annemarie B

机构信息

, Edinburgh, UKUniversity of Edinburgh Medical School.

Centre for Medical Informatics, The Usher Institute, , Edinburgh, UKUniversity of Edinburgh.

出版信息

J Intensive Care Soc. 2023 May;24(2):162-169. doi: 10.1177/17511437211052226. Epub 2021 Oct 24.

Abstract

BACKGROUND

We aimed to compare the prevalence and severity of fatigue in survivors of Covid-19 versus non-Covid-19 critical illness, and to explore potential associations between baseline characteristics and worse recovery.

METHODS

We conducted a secondary analysis of two prospectively collected datasets. The population included was 92 patients who received invasive mechanical ventilation (IMV) with Covid-19, and 240 patients who received IMV with non-Covid-19 illness before the pandemic. Follow-up data were collected post-hospital discharge using self-reported questionnaires. The main outcome measures were self-reported fatigue severity and the prevalence of severe fatigue (severity >7/10) 3 and 12-months post-hospital discharge.

RESULTS

Covid-19 IMV-patients were significantly younger with less prior comorbidity, and more males, than pre-pandemic IMV-patients. At 3-months, the prevalence (38.9% [7/18] vs. 27.1% [51/188]) and severity (median 5.5/10 vs 5.0/10) of fatigue were similar between the Covid-19 and pre-pandemic populations, respectively. At 6-months, the prevalence (10.3% [3/29] vs. 32.5% [54/166]) and severity (median 2.0/10 vs. 5.7/10) of fatigue were less in the Covid-19 cohort. In the total sample of IMV-patients included (i.e. all Covid-19 and pre-pandemic patients), having Covid-19 was significantly associated with less severe fatigue (severity <7/10) after adjusting for age, sex and prior comorbidity (adjusted OR 0.35 (95%CI 0.15-0.76, =0.01).

CONCLUSION

Fatigue may be less severe after Covid-19 than after other critical illness.

摘要

背景

我们旨在比较新冠病毒病(Covid-19)幸存者与非Covid-19危重症患者疲劳的患病率和严重程度,并探讨基线特征与恢复较差之间的潜在关联。

方法

我们对两个前瞻性收集的数据集进行了二次分析。纳入的人群包括92例接受有创机械通气(IMV)的Covid-19患者,以及240例在疫情大流行前接受IMV的非Covid-19疾病患者。出院后使用自我报告问卷收集随访数据。主要结局指标为自我报告的疲劳严重程度以及出院后3个月和12个月时严重疲劳(严重程度>7/10)的患病率。

结果

与疫情大流行前的IMV患者相比,Covid-19的IMV患者明显更年轻,既往合并症更少,男性更多。在3个月时,Covid-19组和疫情大流行前组的疲劳患病率(分别为38.9%[7/18]对27.1%[51/188])和严重程度(中位数5.5/10对5.0/10)相似。在6个月时,Covid-19队列中的疲劳患病率(10.3%[3/29]对32.5%[54/166])和严重程度(中位数2.0/10对5.7/10)较低。在纳入的IMV患者总样本中(即所有Covid-19和疫情大流行前的患者),在调整年龄、性别和既往合并症后,感染Covid-19与较轻的疲劳严重程度(严重程度<7/10)显著相关(调整后的比值比为0.35(95%置信区间0.15 - 0.76,P = 0.01)。

结论

Covid-19后的疲劳可能比其他危重症后的疲劳程度较轻。

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4
Outcomes of acute respiratory distress syndrome in COVID-19 patients compared to the general population: a systematic review and meta-analysis.
Expert Rev Respir Med. 2021 Oct;15(10):1347-1354. doi: 10.1080/17476348.2021.1920927. Epub 2021 May 5.
5
Prevalence and experience of fatigue in survivors of critical illness: a mixed-methods systematic review.
Anaesthesia. 2021 Sep;76(9):1233-1244. doi: 10.1111/anae.15441. Epub 2021 Mar 11.
6
Attributes and predictors of long COVID.
Nat Med. 2021 Apr;27(4):626-631. doi: 10.1038/s41591-021-01292-y. Epub 2021 Mar 10.
7
Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study.
Lancet Respir Med. 2021 Apr;9(4):349-359. doi: 10.1016/S2213-2600(20)30559-2. Epub 2021 Jan 11.
8
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Lancet. 2021 Jan 16;397(10270):220-232. doi: 10.1016/S0140-6736(20)32656-8. Epub 2021 Jan 8.
10
Persistent Symptoms in Patients After Acute COVID-19.
JAMA. 2020 Aug 11;324(6):603-605. doi: 10.1001/jama.2020.12603.

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