Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.
Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, UK.
Development. 2023 Jun 1;150(11). doi: 10.1242/dev.201727.
Across developmental systems, quantitative and imaging-based approaches have provided unprecedented resolution of dynamic changes in gene regulation and cell fate specification, along with complex changes in tissue morphology. This has set the stage for a wealth of comprehensive theoretical models, parameterised by experimental data, able to reproduce key aspects of biological behaviour and jointly enabling a higher level of abstraction, going from the identification of the molecular components to understanding complex functional relationships between these components. Despite these successes, gaining a cross-scale understanding of developmental systems will require further collaboration between disciplines, from developmental biology to bioengineering, systems biology and biophysics. We highlight the exciting multi-disciplinary research discussed at The Company of Biologists workshop 'Fostering quantitative modelling and experimentation in Developmental Biology'.
在不同的发育系统中，基于定量和成像的方法为基因调控和细胞命运特化的动态变化，以及组织形态的复杂变化，提供了前所未有的分辨率。这为大量的综合理论模型奠定了基础，这些模型通过实验数据进行参数化，能够再现生物学行为的关键方面，并共同实现更高层次的抽象，从识别分子成分到理解这些成分之间复杂的功能关系。尽管取得了这些成功，但要全面了解发育系统，还需要从发育生物学到生物工程、系统生物学和生物物理学等不同学科之间进一步合作。我们强调了在 The Company of Biologists 研讨会“促进发育生物学中的定量建模和实验”中讨论的令人兴奋的多学科研究。
