Werner Paul, Kuscu Begüm Sena, Coti Iuliana, Puchner Stefan, Loewe Christian, Schmaranzer Florian, Ad Niv, Laufer Günther, Andreas Martin, Ehrlich Marek
Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
J Thorac Cardiovasc Surg. 2023 Dec;166(6):1635-1643.e1. doi: 10.1016/j.jtcvs.2023.05.024. Epub 2023 May 31.
Biological composite valve grafts (CVGs) are being performed more frequently, which increases the need for interventions treating bioprosthetic valve failure. The feasibility of valve-in-valve procedures in this population is uncertain. This study aimed to assess changes in aortic root geometry and coronary height following CVG implantation to better understand future interventions.
We retrospectively identified 64 patients following bioprosthetic CVG replacement with pre- and postoperative computed tomography angiography. Root assessment was conducted as in preprocedural transcatheter aortic valve evaluation using a virtual valve simulation.
In 64 patients (age, 67.6 ± 9.3 years; 76.6% men) the preoperative coronary height was 14.3 ± 6.8 mm for the left coronary artery (LCA) and 17.9 ± 5.9 mm for the right coronary artery (RCA), which significantly decreased after CVG implantation, with 8.7 ± 4.4 mm for the LCA and 11.3 ± 4.4 mm for the RCA (P < .001). The virtual valve-to-coronary distances measured 4.0 ± 1.3 mm (LCA) and 4.6 ± 1.4 mm (RCA). Overall, 59.4% (n = 38) of patients with bio-CVGs would have been at risk for coronary obstruction, 29.7% (n = 19) for LCA, 10.9% (n = 7) for RCA, and 18.8% (n = 12) for combined LCA and RCA.
Coronary height significantly decreased following CVG implantation. The majority of patients after bio-CVG were at a potential risk for coronary obstruction in future valve-in-valve procedures. Further studies are needed to identify the best possible technique for coronary reimplantation and other measures to diminish the risk for future coronary obstruction in this population.
生物复合瓣膜移植物(CVG)的应用越来越频繁,这增加了治疗生物人工瓣膜功能障碍的干预需求。在这一人群中进行瓣中瓣手术的可行性尚不确定。本研究旨在评估CVG植入术后主动脉根部几何形态和冠状动脉高度的变化,以更好地了解未来的干预措施。
我们回顾性纳入了64例行生物人工CVG置换术的患者,术前行计算机断层扫描血管造影,术后也进行了该检查。使用虚拟瓣膜模拟技术,按照术前经导管主动脉瓣评估的方法进行根部评估。
64例患者(年龄67.6±9.3岁;76.6%为男性),术前左冠状动脉(LCA)的冠状动脉高度为14.3±6.8mm,右冠状动脉(RCA)为17.9±5.9mm,CVG植入后显著降低,LCA为8.7±4.4mm,RCA为11.3±4.4mm(P<0.001)。虚拟瓣膜到冠状动脉的距离分别为4.0±1.3mm(LCA)和4.6±1.4mm(RCA)。总体而言,59.4%(n=38)的生物CVG患者有冠状动脉阻塞风险,其中LCA阻塞风险为29.7%(n=19),RCA为10.9%(n=7),LCA和RCA联合阻塞风险为18.8%(n=12)。
CVG植入术后冠状动脉高度显著降低。大多数生物CVG术后患者在未来的瓣中瓣手术中有冠状动脉阻塞的潜在风险。需要进一步研究以确定冠状动脉再植入的最佳技术以及其他降低该人群未来冠状动脉阻塞风险的措施。