含硫肽：在潜在药物候选物发现中的合成与应用。
Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates.
机构信息
Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
出版信息
Curr Opin Chem Biol. 2023 Aug;75:102336. doi: 10.1016/j.cbpa.2023.102336. Epub 2023 Jun 1.
Peptides act as biological mediators and play a key role of various physiological activities. Sulfur-containing peptides are widely used in natural products and drug molecules due to their unique biological activity and chemical reactivity of sulfur. Disulfides, thioethers, and thioamides are the most common motifs of sulfur-containing peptides, and they have been extensively studied and developed for synthetic methodology as well as pharmaceutical applications. This review focuses on the illustration of these three motifs in natural products and drugs, as well as the recent advancements in the synthesis of the corresponding core scaffolds.
肽作为生物调节剂，在各种生理活动中发挥着关键作用。含硫肽由于其独特的生物活性和硫的化学反应性，在天然产物和药物分子中得到了广泛的应用。二硫键、硫醚和硫酰胺是含硫肽最常见的结构单元，它们在合成方法学以及药物应用方面的研究和开发已经得到了广泛的关注。本文重点介绍了这三种结构单元在天然产物和药物中的应用，以及相应核心骨架合成的最新进展。
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