短期单眼遮盖治疗后单眼弱视眼与非弱视眼视网膜和脉络膜微血管变化的比较。
Comparison of Retinal and Choroidal Microvasculature Changes in Monocular Amblyopic and Non-amblyopic Eyes following Short-term Patch Occlusion Treatment.
机构信息
Department of Ophthalmology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Republic of Korea.
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
出版信息
Curr Eye Res. 2023 Sep;48(9):864-872. doi: 10.1080/02713683.2023.2222231. Epub 2023 Jun 11.
PURPOSE
Our objective was to investigate whether there were differences in the short-term changes of retinal and choroidal microvasculature between amblyopic and non-amblyopic eyes after patch occlusion treatment in patients with monocular amblyopia. Additionally, we aimed to determine if these changes were associated with improvements in clinical parameters.
METHODS
We conducted a retrospective, longitudinal paired-eye case-control study by analyzing the medical records of patients under the age of 12 who had monocular amblyopia and underwent patch occlusion treatment for a duration of 2 to 12 months. Using optical coherence tomography angiography images, we compared the foveal avascular zone width, retinal blood vessel density (VD), choroidal thickness (CT), and choroidal vascularity index (CVI) in amblyopic and non-amblyopic eyes before and after patch occlusion treatment. We analyzed the correlations between the aforementioned parameters and changes in best-corrected visual acuity (BCVA) and stereopsis.
RESULTS
Overall, 114 eyes from 57 patients were enrolled. At baseline, parafoveal superficial plexus VD, foveal and parafoveal deep capillary plexus VD (DCPD) were lower by 0.994 ± 3.312% ( .026), 2.403 ± 8.273% ( .033), and 2.469 ± 4.095% ( .001), respectively; CT was thicker by 30.6 ± 90.7 μm ( = .014); and CVI was higher by 1.920 ± 3.432% ( < 001) in the amblyopic eyes than in the non-amblyopic eyes. Following short-term patch occlusion treatment, foveal and parafoveal DCPD increased by 1.264 ± 3.829% ( = .017) and 1.028 ± 3.662% ( = .036), respectively, CT thinned by 15.5 ± 51.5 μm ( = .019), and CVI decreased by 1.296 ± 3.997% ( = .018) in the amblyopic eyes. Following patch occlusion treatment, as the foveal DCPD decreased and CVI increased, the BCVA improved ( = .017 and .035, respectively).
CONCLUSION
Following patch occlusion treatment, increased foveal DCPD and decreased CVI were associated with improved BCVA.
目的
本研究旨在探讨单眼弱视患者在进行遮盖治疗后，弱视眼和非弱视眼的视网膜和脉络膜微血管在短期的变化是否存在差异。此外，我们还旨在确定这些变化是否与临床参数的改善相关。
方法
我们通过分析年龄在 12 岁以下、接受 2-12 个月遮盖治疗的单眼弱视患者的病历，进行了一项回顾性、纵向配对眼病例对照研究。我们使用光学相干断层扫描血管造影图像，比较了遮盖治疗前后弱视眼和非弱视眼的中心凹无血管区宽度、视网膜血管密度（VD）、脉络膜厚度（CT）和脉络膜血流指数（CVI）。我们分析了上述参数与最佳矫正视力（BCVA）和立体视的变化之间的相关性。
结果
共有 57 例患者的 114 只眼纳入研究。在基线时，旁中心凹浅层脉络膜血管丛 VD、中心凹和旁中心凹深层毛细血管丛 VD（DCPD）分别下降了 0.994 ± 3.312%（ .026）、2.403 ± 8.273%（ .033）和 2.469 ± 4.095%（ .001）；CT 增厚了 30.6 ± 90.7 μm（ = .014）；CVI 升高了 1.920 ± 3.432%（ < 001）。短期遮盖治疗后，弱视眼的中心凹和旁中心凹 DCPD 分别增加了 1.264 ± 3.829%（ = .017）和 1.028 ± 3.662%（ = .036），CT 变薄了 15.5 ± 51.5 μm（ = .019），CVI 降低了 1.296 ± 3.997%（ = .018）。遮盖治疗后，随着中心凹 DCPD 的降低和 CVI 的升高，BCVA 得到改善（ = .017 和.035）。
结论
遮盖治疗后，中心凹 DCPD 的增加和 CVI 的降低与 BCVA 的改善相关。
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