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免疫耐受树突状细胞报告:最小信息模型是否产生了影响?

Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?

机构信息

School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom.

Translational & Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.

出版信息

PeerJ. 2023 May 31;11:e15352. doi: 10.7717/peerj.15352. eCollection 2023.

Abstract

Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work. In 2016, Minimum Information about Tolerogenic Antigen-Presenting cells (MITAP) was created to standardize the reporting on tolerogenic antigen-presenting cells, including tolerogenic dendritic cells (tolDCs). tolDCs is a generic term for dendritic cells that have the ability to (re-)establish immune tolerance; they have been developed as a cell therapy for autoimmune diseases or for the prevention of transplant rejection. Because protocols to generate these therapeutic cells vary widely, MITAP was deemed to be a pivotal reporting tool by and for the tolDC community. In this paper, we explored the impact that MITAP has had on the tolDC field. We did this by examining a subset of the available literature on tolDCs. Our analysis shows that MITAP is used in only the minority of relevant papers (14%), but where it is used the amount of metadata available is slightly increased over where it is not. From this, we conclude that MITAP has been a partial success, but that much more needs to be done if standardized reporting is to become common within the discipline.

摘要

最小信息模型是一种报告框架,用于描述出版物中需要提供的基本信息,以便对工作进行重复或与其他工作进行比较。2016 年,创建了最小信息关于耐受性抗原呈递细胞 (MITAP) 以标准化耐受性抗原呈递细胞的报告,包括耐受性树突状细胞 (tolDC)。tolDC 是一种具有(重新)建立免疫耐受能力的树突状细胞的通用术语;它们已被开发为用于自身免疫性疾病的细胞治疗或用于预防移植排斥反应。由于生成这些治疗性细胞的方案差异很大,因此 MITAP 被认为是 tolDC 社区的重要报告工具。在本文中,我们探讨了 MITAP 对 tolDC 领域的影响。我们通过检查 tolDC 相关文献的一部分子集来做到这一点。我们的分析表明,MITAP 仅在少数相关论文中使用(14%),但在使用 MITAP 的情况下,可用元数据的数量略高于未使用 MITAP 的情况。由此得出结论,MITAP 取得了一定的成功,但如果要在该学科内实现标准化报告,还有很多工作要做。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0faa/10239229/d8299e9657bf/peerj-11-15352-g001.jpg

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