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韩国复苏性血管内球囊阻断主动脉术治疗不稳定骨盆骨折的早期经验:一项多机构研究。

Early experience with resuscitative endovascular balloon occlusion of the aorta for unstable pelvic fractures in the Republic of Korea: a multi-institutional study.

机构信息

Division of Trauma Surgery, Department of Surgery, Dankook University College of Medicine, Cheonan, Republic of Korea.

Division of Trauma Surgery, Department of Surgery, Ajou School of Medicine, 164 Worldcup-Ro, Yeongtong-Gu, Suwon-Si, Gyeonggi-Do, 16499, Republic of Korea.

出版信息

Eur J Trauma Emerg Surg. 2023 Dec;49(6):2495-2503. doi: 10.1007/s00068-023-02293-x. Epub 2023 Jun 5.

Abstract

PURPOSE

Recently, trauma centers in the Republic of Korea introduced resuscitative endovascular balloon occlusion of the aorta (REBOA) for application in severe pelvic fracture cases. This study aimed to determine the efficacy of REBOA and its associated factors in enhancing survival.

METHODS

Data from patients with severe pelvic injuries at two regional trauma centers from 2016 to 2020 were retrospectively reviewed. Patients were dichotomized into REBOA and no-REBOA groups, and patient characteristics and clinical outcomes were compared using 1:1 propensity score matching. Additional survival-based analysis was performed in the REBOA group.

RESULTS

REBOA was performed in 42 of the 174 patients with pelvic fractures. As patients in the REBOA group had more severe injuries than did patients in the no-REBOA group, 1:1 propensity score matching was performed to adjust for severity. After matching, 24 patients were included in each group and mortality was not significantly different (REBOA 62.5% vs. no-REBOA 41.7%, P = 0.149). Kaplan-Meier analysis revealed no significant differences in mortality between the two matched groups (log-rank test, P = 0.408). Among the 42 patients treated with REBOA, 14 survived. Shorter REBOA duration (63 [40-93] vs. 166 [67-193] min, P = 0.015) and higher systolic blood pressure before REBOA (65 [58-76] vs. 54 [49-69] mmHg, P = 0.035) were associated with better survival.

CONCLUSIONS

The effectiveness of REBOA has not been definitively established; however, it was not associated with increased mortality in this study. Additional studies are required to better understand how REBOA can be effectively used for treatment.

摘要

目的

最近,韩国的一些创伤中心开始将主动脉球囊阻断复苏术(REBOA)应用于严重骨盆骨折病例。本研究旨在确定 REBOA 的疗效及其在提高生存率方面的相关因素。

方法

回顾性分析了 2016 年至 2020 年在两个地区创伤中心就诊的严重骨盆损伤患者的数据。将患者分为 REBOA 组和非 REBOA 组,采用 1:1 倾向评分匹配比较患者特征和临床结局。在 REBOA 组进行了基于生存的额外分析。

结果

在 174 例骨盆骨折患者中,有 42 例患者接受了 REBOA 治疗。由于 REBOA 组患者的损伤比非 REBOA 组患者更严重,因此进行了 1:1 倾向评分匹配以调整严重程度。匹配后,每组纳入 24 例患者,死亡率无显著差异(REBOA 组为 62.5%,非 REBOA 组为 41.7%,P=0.149)。Kaplan-Meier 分析显示,两组匹配患者的死亡率无显著差异(对数秩检验,P=0.408)。在接受 REBOA 治疗的 42 例患者中,有 14 例存活。REBOA 持续时间较短(63[40-93] vs. 166[67-193]min,P=0.015)和 REBOA 前收缩压较高(65[58-76] vs. 54[49-69]mmHg,P=0.035)与更好的生存率相关。

结论

REBOA 的有效性尚未得到明确证实;然而,在本研究中,它与死亡率增加无关。需要进一步研究以更好地了解如何有效地将 REBOA 用于治疗。

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