Department of Hygiene and Public Health, Teikyo University School of Medicine.
Tohoku Institute for Management of Blood Pressure.
Tohoku J Exp Med. 2023 Aug 9;260(4):273-282. doi: 10.1620/tjem.2023.J045. Epub 2023 Jun 8.
The Ohasama Study is a long-term prospective cohort study of the general population in the town of Ohasama (currently, Hanamaki city) in Iwate Prefecture, Japan, that was started in 1986. Ohasama is a typical farming village in the Tohoku region that consists of part-time farming households that cultivate mainly fruit trees. At the start of the study, the prevention of hypertension, a main cause of strokes, was taken to be an important issue in public health activities because of the many people who died or needed care as a result of strokes in Ohasama. A home blood pressure measurement program was then begun with the aim of preventing hypertension while increasing a sense of solidarity among community residents and the awareness that "one must protect one's own health." As a result, this project became the world's first community-based epidemiological study using home blood pressure, as well as 24-hour ambulatory blood pressure, for which measurements were also initiated. In the 1990s, the Ohasama Study reported a linear "the lower, the better" relationship between out-of-office blood pressure and cardiovascular risk. To date, we have accumulated advanced evidence regarding the clinical significance of out-of-office blood pressure. Those have contributed to hypertension management guidelines around the world. This article summarizes the results of representative long-term follow-up studies of the Ohasama Study.
大沼研究是一项针对日本岩手县大沼町（现花卷市）普通人群的长期前瞻性队列研究，始于 1986 年。大沼是东北地区一个典型的农业村，有部分时间从事农业的家庭，主要种植果树。在研究开始时，由于大沼有许多人因中风而死亡或需要护理，预防中风的主要病因高血压成为公共卫生活动的重要问题。随后开始了家庭血压测量计划，旨在预防高血压的同时增强社区居民的团结意识和“必须保护自己健康”的意识。因此，该项目成为世界上第一个使用家庭血压和 24 小时动态血压进行的基于社区的流行病学研究，也同时开始了这些测量。20 世纪 90 年代，大沼研究报告了非工作时间血压与心血管风险之间呈线性“越低越好”的关系。迄今为止，我们已经积累了有关非工作时间血压的临床意义的先进证据。这些证据为世界各地的高血压管理指南做出了贡献。本文总结了大沼研究的一些具有代表性的长期随访研究结果。
