Department of Chemistry, Faculty of Science, Hokkaido University, Kita 10 Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810, Japan.
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Kita 21 Nishi 10, Kita-ku, Sapporo, Hokkaido 001-0021, Japan.
Org Lett. 2023 Jun 23;25(24):4581-4585. doi: 10.1021/acs.orglett.3c01645. Epub 2023 Jun 8.
Photoinduced -internal vicinal aminochlorination of styrene-type terminal alkenes was developed. The reaction proceeded without any catalyst, and the use of -chloro(fluorenone imine) as both a photoactivatable aminating agent and a chlorinating agent was essential. The imine moiety, introduced at the internal position of the alkenes, could be hydrolyzed under mild conditions to provide versatile β-chlorinated primary amines, the synthetic utility of which was demonstrated by several transformations.
发展了一种光诱导的苯乙烯型末端烯烃的偕位氨基氯代反应。该反应无需任何催化剂，且使用 - 氯（芴酮亚胺）作为光活化的胺化剂和氯化剂是必不可少的。亚胺部分引入到烯烃的内部位置，在温和条件下可以水解，从而提供了多功能的β-氯代伯胺，其通过几种转化反应证明了其合成实用性。
