Cardiology Department, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, 230032, China.
Cardiology Department, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, 230032, China.
Am J Med Sci. 2023 Sep;366(3):176-184. doi: 10.1016/j.amjms.2023.04.034. Epub 2023 Jun 7.
Myocardial ischemia-reperfusion injury (MIRI) is a serious complication affecting the prognosis of patients with myocardial infarction and can cause cardiac arrest, reperfusion arrhythmias, no-reflow, and irreversible myocardial cell death. Ferroptosis, an iron-dependent, peroxide-driven, non-apoptotic form of regulated cell death, plays a vital role in reperfusion injury. Acetylation, an important post-translational modification, participates in many cellular signaling pathways and diseases, and plays a pivotal role in ferroptosis. Elucidating the role of acetylation in ferroptosis may therefore provide new insights for the treatment of MIRI. Here, we summarized the recently discovered knowledge about acetylation and ferroptosis in MIRI. Finally, we focused on the acetylation modification during ferroptosis and its potential relationship with MIRI.
心肌缺血再灌注损伤（MIRI）是影响心肌梗死患者预后的严重并发症，可引起心脏骤停、再灌注心律失常、无复流和心肌细胞不可逆死亡。铁死亡是一种铁依赖性、过氧化物驱动的、非凋亡形式的细胞程序性死亡，在再灌注损伤中起着至关重要的作用。乙酰化是一种重要的翻译后修饰，参与许多细胞信号通路和疾病，在铁死亡中起着关键作用。因此，阐明乙酰化在铁死亡中的作用可能为 MIRI 的治疗提供新的思路。本文总结了近年来关于 MIRI 中铁死亡和乙酰化的相关知识，重点探讨了铁死亡过程中的乙酰化修饰及其与 MIRI 的潜在关系。
