College of Life Sciences, Wuhan University, Wuhan 430072, China.
Molecules. 2023 May 30;28(11):4432. doi: 10.3390/molecules28114432.
The circadian clock regulates daily changes in behavioral, endocrine, and metabolic activities in mammals. Circadian rhythms in cellular physiology are significantly affected by aging. In particular, we previously found that aging has a profound impact on daily rhythms in mitochondrial functions in mouse liver, leading to increased oxidative stress. This is not due to molecular clock malfunctions in peripheral tissues in old mice, however, as robust clock oscillations are observed therein. Nonetheless, aging induces changes in gene expression levels and rhythms in peripheral and probably central tissues. In this article, we review recent findings on the roles of the circadian clock and the aging process in regulating mitochondrial rhythms and redox homeostasis. Chronic sterile inflammation is implicated in mitochondrial dysfunction and increased oxidative stress during aging. In particular, upregulation of the NADase CD38 by inflammation during aging contributes to mitochondrial dysregulation.
生物钟调节哺乳动物的行为、内分泌和代谢活动的日常变化。细胞生理学中的昼夜节律受衰老的显著影响。特别是，我们之前发现，衰老对小鼠肝脏中线粒体功能的日常节律有深远的影响，导致氧化应激增加。然而，这并不是由于老年小鼠外周组织中的分子钟功能障碍，因为在其中观察到了稳健的时钟振荡。尽管如此，衰老会引起外周组织（可能还有中枢组织）中基因表达水平和节律的变化。在本文中，我们回顾了生物钟和衰老过程在调节线粒体节律和氧化还原平衡中的作用的最新发现。慢性无菌性炎症与衰老过程中线粒体功能障碍和氧化应激增加有关。特别是，炎症期间 NADase CD38 的上调导致线粒体失调。
