Richardson P J, Wodak A D, Atkinson L, Saunders J B, Jewitt D E
Br Heart J. 1986 Aug;56(2):165-70. doi: 10.1136/hrt.56.2.165.
Detailed drinking histories were taken in 38 patients in whom dilated cardiomyopathy was diagnosed by cardiac catheterisation and left ventricular biopsy. On the basis of the drinking history twenty patients were classified as being in an abstinent or light drinking group and eighteen patients as being in a heavy drinking group (daily alcohol intake in excess of 80 g or cumulative lifetime intake exceeding 250 kg). Activities of myocardial creatine kinase, lactate dehydrogenase, alpha hydroxybutyric dehydrogenase, malic dehydrogenase, and aspartate amino-transferase were all higher in the heavy drinkers and myocardial enzyme activity correlated with cumulative lifetime alcohol intake, maximum daily intake, and recent daily intake. Activities of creatine kinase, alpha hydroxybutyric dehydrogenase, and malic dehydrogenase correlated with ejection fraction, irrespective of the alcohol intake of the patient. These findings were not altered by exclusion of patients with hypertension. The results indicate that among patients with dilated cardiomyopathy there is a group characterised by a high alcohol intake and raised myocardial tissue enzymes which supports the concept of alcoholic heart muscle disease as a distinct entity.
对38例经心导管检查和左心室活检诊断为扩张型心肌病的患者进行了详细的饮酒史调查。根据饮酒史，20例患者被归类为戒酒或轻度饮酒组，18例患者被归类为重度饮酒组（每日酒精摄入量超过80克或终生累积摄入量超过250千克）。重度饮酒者的心肌肌酸激酶、乳酸脱氢酶、α-羟丁酸脱氢酶、苹果酸脱氢酶和天冬氨酸转氨酶活性均较高，心肌酶活性与终生累积酒精摄入量、最大每日摄入量和近期每日摄入量相关。肌酸激酶、α-羟丁酸脱氢酶和苹果酸脱氢酶的活性与射血分数相关，与患者的酒精摄入量无关。排除高血压患者后，这些发现没有改变。结果表明，在扩张型心肌病患者中，有一组患者的特点是酒精摄入量高且心肌组织酶升高，这支持了酒精性心肌病作为一种独特疾病实体的概念。
