Lu Zhimin, Wang Hao, Gong Zhangyun, Guo Peipei, Li Caihua, Bi Kaihuan, Li Xuqing, Chen Ya, Pan Anan, Xu Yuping, Zhou Ping, Wei Zhaolian, Jiang Huanhuan, Cao Yunxia
Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Wanshui Road No.120, Hefei 230000, China; NHC Key Laboratory of Study on ABNORMAL gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China.
Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Wanshui Road No.120, Hefei 230000, China; NHC Key Laboratory of Study on ABNORMAL gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China; Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China.
Int Immunopharmacol. 2023 Aug;121:110421. doi: 10.1016/j.intimp.2023.110421. Epub 2023 Jun 9.
Innate lymphoid cells (ILCs) are a kind of lymphocytes that reside in the tissue and have an essential function in the immune microenvironment. However, the relationship between endometriosis (EMS) and ILCs is complex and not fully understood. This study examines several groups of ILCs in the peripheral blood (PB), peritoneal fluid (PF) and endometrium of patients with EMS via flow cytometry. The study observed an increase in PB ILCs, particularly ILC2s and ILCregs subsets and Arg1ILC2s in the EMS patients were highly activated. EMS patients had significantly higher levels of serum interleukin (IL)-10/33/25 compared to controls. We also found an elevation of Arg1ILC2s in the PF and higher levels of ILC2s and ILCregs in ectopic endometrium compared with eutopic. Importantly, a positive correlation was observed between the enrichment of Arg1ILC2s and ILCregs in the PB of EMS patients. The findings indicate that the involvement of Arg1ILC2s and ILCregs fosters potentially endometriosis progression.
固有淋巴细胞（ILCs）是一类存在于组织中的淋巴细胞，在免疫微环境中发挥着重要作用。然而，子宫内膜异位症（EMS）与ILCs之间的关系复杂且尚未完全明确。本研究通过流式细胞术检测了EMS患者外周血（PB）、腹腔液（PF）和子宫内膜中的几组ILCs。研究观察到EMS患者外周血ILCs增加，尤其是ILC2s和ILCregs亚群，且EMS患者的精氨酸酶1阳性ILC2s（Arg1ILC2s）高度活化。与对照组相比，EMS患者血清白细胞介素（IL）-10/33/25水平显著更高。我们还发现，与在位内膜相比，PF中Arg1ILC2s升高，异位内膜中ILC2s和ILCregs水平更高。重要的是，在EMS患者外周血中，观察到Arg1ILC2s和ILCregs的富集之间呈正相关。这些发现表明，Arg1ILC2s和ILCregs的参与可能促进子宫内膜异位症的进展。
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