一名IV期子宫癌患者拒绝合理化疗和免疫检查点抑制剂治疗，采用自体福尔马林固定肿瘤疫苗进行单药治疗取得成功。
Successful monotherapy with autologous formalin-fixed tumor vaccine for a Stage IV uterine cancer patient who rejected rational chemotherapy and immune checkpoint inhibitor treatment.
作者信息
Fukuda Katsuhiko, Ohno Tadao
机构信息
Integrated Medical Center Fukuda Internal Medicine Clinic Matsue-shi Japan.
Cell-Medicine, Inc. Tsukuba Science City Japan.
出版信息
Clin Case Rep. 2023 Jun 8;11(6):e7513. doi: 10.1002/ccr3.7513. eCollection 2023 Jun.
Abstract
KEY CLINICAL MESSAGE
To overcome patient-initiated treatment refusal because of fear of experiencing severe negative adverse events, mild immunotherapy using a cancer vaccine such as the autologous formalin-fixed tumor vaccine should be considered.
ABSTRACT
A patient who refused chemotherapy and immune checkpoint inhibitor treatment for Stage IV uterine cancer after displaying circulating tumor cells and high microsatellite instability received monotherapy with autologous formalin-fixed tumor vaccine (AFTV). Following treatment, we observed regression of multiple lung metastases, suggesting that AFTV is an attractive treatment option.
摘要
关键临床信息
为克服因担心出现严重不良事件而由患者发起的治疗拒绝情况，应考虑使用癌症疫苗（如自体福尔马林固定肿瘤疫苗）进行温和免疫治疗。
摘要
一名IV期子宫癌患者在出现循环肿瘤细胞和高微卫星不稳定性后拒绝化疗和免疫检查点抑制剂治疗，接受了自体福尔马林固定肿瘤疫苗（AFTV）单药治疗。治疗后，我们观察到多处肺转移灶消退，表明AFTV是一种有吸引力的治疗选择。
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Rate of Clinical Complete Response for 1 Year or More in Bone-Metastatic Breast Cancer after Comprehensive Treatments including Autologous Formalin-Fixed Tumor Vaccine.
Int J Breast Cancer. 2018 Jan 22;2018:4879406. doi: 10.1155/2018/4879406. eCollection 2018.
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