MGMT 甲基化的高级别胶质瘤伴远处复发及原发肿瘤部位稳定：病例系列
MGMT Methylated High Grade Glioma with Distant Recurrence and Stable Original Tumor Site: Case Series.
作者信息
Lee Jonathan, Lukas Rimas V, Jusue-Torres Ignacio, Germanwala Anand V, Borys Ewa, Solanki Abhishek A, Mallik Atul K, Barton Kevin, Thakkar Jigisha P
机构信息
Department of Neurological Surgery, Loyola University Medical Center/Stritch School of Medicine, Maywood, IL, USA.
Department of Neurology, Northwestern University, USA.
出版信息
Ann Hematol Oncol. 2023;10(2). doi: 10.26420/annhematoloncol.2023.1421. Epub 2023 Apr 29.
We present three cases of O-Methylguanine-DNA Methyl-transferase (MGMT) methylated high grade gliomas with distant recurrence. All three patients had a radiographic stability of original tumor site at time of distant recurrence indicating impressive local control with Stupp protocol in patients with a MGMT methylated tumors. All patients had a poor outcome after distant recurrence. For one patient Next Generation Sequencing (NGS) was available for both original and recurrent tumor and did not reveal any difference other than high tumor mutational burden in the distant recurrent tumor. Understanding risk factors of distant recurrence in MGMT methylated tumors and investigating correlations between recurrences will help plan therapeutic strategies to prevent distant recurrence and improve survival of these patients.
我们报告了3例O-甲基鸟嘌呤-DNA甲基转移酶（MGMT）甲基化的高级别胶质瘤发生远处复发的病例。所有3例患者在远处复发时，其原发肿瘤部位在影像学上保持稳定，这表明采用Stupp方案对MGMT甲基化肿瘤患者进行治疗可实现令人满意的局部控制。所有患者在远处复发后预后均较差。对于1例患者，可获得原发肿瘤和复发性肿瘤的二代测序（NGS）结果，结果显示除远处复发性肿瘤的肿瘤突变负荷较高外，未发现其他差异。了解MGMT甲基化肿瘤远处复发的危险因素并研究复发之间的相关性，将有助于制定治疗策略以预防远处复发并提高这些患者的生存率。
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