Whyte Claire S
Aberdeen Cardiovascular and Diabetes Centre, The Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.
Front Med (Lausanne). 2023 Jun 2;10:1212201. doi: 10.3389/fmed.2023.1212201. eCollection 2023.
The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens. The awareness of these interlinked process has resulted in the coining of the terms "thromboinflammation" and "immunothrombosis." Once a thrombus is formed it is up to the fibrinolytic system to resolve these clots and remove them from the vasculature. Immune cells contain an arsenal of fibrinolytic regulators and plasmin, the central fibrinolytic enzyme. The fibrinolytic proteins in turn have diverse roles in immunoregulation. Here, the intricate relationship between the fibrinolytic and innate immune system will be discussed.
止血系统和先天免疫系统是相互交织的过程。血管内的炎症促进血栓形成，而纤维蛋白是先天免疫反应的一部分，用于捕获入侵的病原体。对这些相互关联过程的认识导致了“血栓炎症”和“免疫血栓形成”这两个术语的出现。一旦形成血栓，就由纤维蛋白溶解系统来溶解这些凝块并将它们从血管中清除。免疫细胞含有一系列纤维蛋白溶解调节因子和纤溶酶（核心纤维蛋白溶解酶）。反过来，纤维蛋白溶解蛋白在免疫调节中具有多种作用。在此将讨论纤维蛋白溶解系统与先天免疫系统之间的复杂关系。
