通过硅基芳基氰醇与环氧化物的烷基化反应制备β-羟基酮（醛醇）。
Preparation of β-Hydroxyketones (Aldols) from the Alkylation of -Silyl Aryl Cyanohydrins with Epoxides.
作者信息
Gilreath Lissa D, Melendez Diamond R, McGlade Caylie A, Shoemaker Jennifer E, Mullinax Dakoda W, Hartel Aaron M
机构信息
Department of Chemistry, Winthrop University, Rock Hill, SC 29733, USA.
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
出版信息
Tetrahedron Lett. 2023 Feb 17;116. doi: 10.1016/j.tetlet.2022.154334. Epub 2022 Dec 28.
Abstract
β-Hydroxyketones (aldols) are prepared from the alkylation-deprotection of -silylated aryl cyanohydrins with epoxides. Key to the success of the method was the suppression of an cyclic imidate formation that occurs upon initial opening of the epoxide ring.
摘要
β-羟基酮（醛醇）由硅烷基化芳基氰醇与环氧化物进行烷基化-脱保护反应制得。该方法成功的关键在于抑制环氧化物环初始开环时发生的环状亚胺酯形成。
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