肥胖与餐后胰多肽分泌受损有关。
Obesity is associated with impaired postprandial pancreatic polypeptide secretion.
机构信息
Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, China.
Medical Research Center, Qingdao Key Laboratory of Thyroid Diseases, Qingdao, China.
出版信息
Front Endocrinol (Lausanne). 2023 Jun 2;14:1192311. doi: 10.3389/fendo.2023.1192311. eCollection 2023.
OBJECTIVE
This study aims to compare the levels of serum pancreatic polypeptide (PP), insulin (INS), C-peptide (C-P), and glucagon (GCG) before and after glucose stimulation in type 2 diabetes mellitus (T2DM) patients with different body mass indexes (BMI), analyze the relevant factors associated with PP secretion, and further investigate the role of PP in the development of obesity and diabetes.
METHODS
Data were collected from 83 patients from the hospital. The subjects were divided into normal-weight group, overweight group, and obese group according to their BMI. All subjects were tested with the standard bread meal test (SBMT). PP and relevant parameters were measured, and the area under the curve (AUC) was calculated after 120 min of SBMT. AUC (AUC of PP) was used as the dependent variable, and the potential influencing factors were used as independent variables for multiple linear regression analysis.
RESULTS
The obese and overweight groups had significantly lower PP secretion than the normal-weight group (485.95 pg·h/ml, 95% CI 76.16-895.74, = 0.021; 664.61 pg·h/ml, 95% CI 285.46-1043.77, = 0.001) at 60 min postprandial. PP secretion in the obese and overweight groups was also significantly lower than that in the normal-weight group (520.07 pg·h/ml, 95% CI 186.58-853.56, = 0.003; 467.62 pg·h/ml, 95% CI 159.06-776.18, = 0.003) at 120 min postprandial. AUC was negatively associated with BMI (r = -0.260, = 0.017) and positively associated with AUC (r = 0.501, 0.001). Multiple linear regression analysis showed that there was a linear correlation between AUC, BMI, and AUC ( 0.001, = 0.008). The regression equation was calculated as follows: AUC = 1772.255-39.65 × BMI + 0.957 × AUC (R54.1%, 0.001).
CONCLUSION
Compared with normal-weight subjects, overweight and obese subjects had impaired PP secretion after glucose stimulation. In T2DM patients, PP secretion was mainly affected by BMI and GCG.
CLINICAL TRIAL REGISTRY
The Ethics Committee of the Affiliated Hospital of Qingdao University.
CLINICAL TRIAL REGISTRATION
http://www.chictr.org.cn, identifier ChiCTR2100047486.
目的
本研究旨在比较不同体重指数（BMI）的 2 型糖尿病（T2DM）患者在葡萄糖刺激前后血清胰多肽（PP）、胰岛素（INS）、C 肽（C-P）和胰高血糖素（GCG）水平，分析与 PP 分泌相关的因素，并进一步探讨 PP 在肥胖和糖尿病发展中的作用。
方法
从医院收集了 83 名患者的数据。根据 BMI 将受试者分为正常体重组、超重组和肥胖组。所有受试者均接受标准面包餐试验（SBMT）检测。测量 PP 及相关参数，并计算 SBMT 后 120 min 的曲线下面积（AUC）。以 AUC（PP 的 AUC）为因变量，以潜在影响因素为自变量进行多元线性回归分析。
结果
餐后 60 min，肥胖组和超重组的 PP 分泌明显低于正常体重组（485.95 pg·h/ml，95%CI 76.16-895.74， = 0.021；664.61 pg·h/ml，95%CI 285.46-1043.77， = 0.001）。餐后 120 min，肥胖组和超重组的 PP 分泌也明显低于正常体重组（520.07 pg·h/ml，95%CI 186.58-853.56， = 0.003；467.62 pg·h/ml，95%CI 159.06-776.18， = 0.003）。AUC 与 BMI 呈负相关（r = -0.260， = 0.017），与 AUC 呈正相关（r = 0.501， 0.001）。多元线性回归分析显示，AUC、BMI 和 AUC 之间存在线性关系（ 0.001， = 0.008）。计算回归方程如下：AUC = 1772.255-39.65 × BMI + 0.957 × AUC（R54.1%， 0.001）。
结论
与正常体重受试者相比，超重和肥胖的葡萄糖刺激后 PP 分泌受损。在 T2DM 患者中，PP 分泌主要受 BMI 和 GCG 影响。
临床试验注册
青岛大学附属医院伦理委员会。
临床试验注册
http://www.chictr.org.cn，标识符 ChiCTR2100047486。
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