Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
J Alzheimers Dis. 2023;94(2):763-775. doi: 10.3233/JAD-221166.
Gender, APOE ɛ4 status and age have different effects on brain amyloid deposition in patients with mild cognitively impaired (MCI).
To investigate the effect of gender×APOE ɛ4 status interaction on Aβ deposition in the brains of individuals with MCI in different age groups by PET scanning.
204 individuals with MCI were classified into younger or older groups based on whether they were under or over 65 years of age. APOE genotyping, structural MRI, amyloid PET scans, and neuropsychological tests were performed. The effect of gender×APOE ɛ4 status interaction on Aβ deposition was assessed in different age groups.
APOE ɛ4 carriers had higher amyloid deposition than noncarriers in the whole group. Females with MCI had more amyloid deposition in the medial temporal lobe than males in the whole cohort and younger group. Older individuals with MCI had higher amyloid deposition than younger individuals. In stratified analysis by age, female APOE ɛ4 carriers had significantly increased amyloid deposition compared to their male counterparts only in the medial temporal lobe in the younger group. Amyloid deposition was increased in female APOE ɛ4 carriers compared to noncarriers in the younger group, whereas higher amyloid deposition was observed in male APOE ɛ4 carriers in the older group.
Women in the younger group with MCI who were APOE ɛ4 carriers had more amyloid deposition in the brain, while men in the older group with MCI who were APOE ɛ4 carriers had higher amyloid deposition.
性别、APOEɛ4 状态和年龄对轻度认知障碍（MCI）患者的脑淀粉样蛋白沉积有不同影响。
通过 PET 扫描研究性别×APOEɛ4 状态相互作用对不同年龄组 MCI 个体脑内 Aβ 沉积的影响。
根据是否 65 岁以上，将 204 名 MCI 患者分为年轻组或老年组。进行 APOE 基因分型、结构 MRI、淀粉样蛋白 PET 扫描和神经心理学测试。评估不同年龄组中性别×APOEɛ4 状态相互作用对 Aβ 沉积的影响。
APOEɛ4 携带者在整个组中比非携带者具有更高的淀粉样蛋白沉积。在整个队列和年轻组中，女性 MCI 患者的内侧颞叶淀粉样蛋白沉积高于男性。老年 MCI 患者的淀粉样蛋白沉积高于年轻患者。在按年龄分层的分析中，仅在年轻组中，女性 APOEɛ4 携带者的内侧颞叶淀粉样蛋白沉积明显高于男性携带者。与非携带者相比，年轻组中女性 APOEɛ4 携带者的淀粉样蛋白沉积增加，而老年组中男性 APOEɛ4 携带者的淀粉样蛋白沉积增加。
年轻组中携带 APOEɛ4 的女性 MCI 患者脑内淀粉样蛋白沉积更多，而老年组中携带 APOEɛ4 的男性 MCI 患者脑内淀粉样蛋白沉积更多。
