School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Department of Physics, Government Arts and Science College for Women, Karimngalam-635111, Dharmapuri, Tamil Nadu, India.
Int J Biol Macromol. 2023 Jul 31;244:125467. doi: 10.1016/j.ijbiomac.2023.125467. Epub 2023 Jun 17.
The dual stimuli-responsive drug delivery system has attracted a lot of interest in controlled drug delivery to specific sites. The magnetic iron oxide nanoparticles integrated polyelectrolyte complex-based hydrogel (MPEC HG) system was developed in this work. First, magnetic nanoparticles were produced in situ in the synthetic polymer polyhexamethylene guanidine (PHMG). Furthermore, the natural biopolymer k-carrageenan (kCG) was employed to form the polyelectrolyte complex (PEC) through charge-balancing interaction between positively charged guanidine units and negatively charged sulfonate groups. Various characterization approaches were used to characterize the developed magnetic polyelectrolyte complex hydrogel (MPEC HG) system. Curcumin (Cur) was employed as a model bioactive agent to examine the drug loading and stimuli-responsive drug release efficiency of the MPEC HG system. Under the combined pH and temperature stimuli conditions (pH 5.0/42 °C), the developed hydrogel system demonstrated great drug loading efficiency (∼ 68 %) and enhanced drug release. Furthermore, the MPEC HG system's in vitro cytotoxicity behavior was investigated on a human liver cancer (HepG2) cell line, and the results revealed that the MPEC HG system is biocompatible. As a result, the MPEC HG system might be used for dual pH and temperature stimuli-responsive drug delivery applications in cancer therapy.
双刺激响应药物递送系统在向特定部位控制药物递送方面引起了广泛关注。本工作中开发了一种基于磁性氧化铁纳米粒子整合聚电解质复合物的水凝胶（MPEC HG）系统。首先，在合成聚合物聚六亚甲基胍（PHMG）中就地生成磁性纳米粒子。此外，天然生物聚合物κ-卡拉胶（kCG）通过带正电荷的胍基单元与带负电荷的磺酸根之间的电荷平衡相互作用形成聚电解质复合物（PEC）。采用各种表征方法对所开发的磁性聚电解质复合物水凝胶（MPEC HG）系统进行了表征。姜黄素（Cur）被用作模型生物活性药物，以考察 MPEC HG 系统的药物负载和刺激响应药物释放效率。在 pH 5.0/42°C 的联合 pH 和温度刺激条件下，所开发的水凝胶系统表现出高的药物负载效率（约 68%）和增强的药物释放。此外，还研究了 MPEC HG 系统在人肝癌（HepG2）细胞系上的体外细胞毒性行为，结果表明 MPEC HG 系统具有生物相容性。因此，MPEC HG 系统可能用于癌症治疗中的双 pH 和温度刺激响应药物递送应用。
