Key Laboratory of Evaluation of Chinese Medicine Efficacy (Prevention and Treatment of Brain Disease with Mental Disorders), Key Laboratory of Depression Animal Model Based on TCM Syndrome, Jiangxi Administration of Chinese Medicine, Key Laboratory of TCM for Prevention and Treatment of Brain Diseases with Cognitive Dysfunction, Jiangxi University of Chinese Medicine, 1688 Meiling Road, Nanchang 330006, Jiangxi Province, China.
Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China.
Fitoterapia. 2023 Sep;169:105583. doi: 10.1016/j.fitote.2023.105583. Epub 2023 Jun 17.
Phytochemical investigation of the volatile oil of Yueju (YJVO) and its constituent herbs induced the detection of 52 compounds in YJVO, mainly monoterpenes and sesquiterpenes as well as a small amount of aromatic and aliphatic compounds. 5 of these compounds were found only in the YJVO instead of the volatile oil of its constituent herbs. The anti-depressant effect of YJVO was proved by behavioral tests in chronic unpredictable mild stress (CUMS) mice. An acute oral toxicity evaluation determined the LD of YJVO was 5.780 mL/kg. Doppler ultrasound and laser speckle imaging have detected that the YJVO could improve depression-related cerebral blood flow. In addition, related neurotransmitters and proteins were analyzed through targeted metabolomics and immunofluorescence. The potential antidepressant mechanisms of YJVO related to significantly decreasing Glu in CUMS mice by up-regulating the ERK/AKT-mediated expression of GLT-1.
月橘挥发油及其组成草药的化学成分研究，通过检测，月橘挥发油中主要含有单萜类、倍半萜类化合物以及少量的芳香族和脂肪族化合物，52 种化合物。其中 5 种化合物仅存在于月橘挥发油中，而不存在于其组成草药的挥发油中。通过慢性不可预知性轻度应激（CUMS）小鼠的行为测试，证明了月橘挥发油的抗抑郁作用。急性口服毒性评价确定了月橘挥发油的 LD 为 5.780 mL/kg。多普勒超声和激光散斑成像检测到月橘挥发油可以改善与抑郁相关的脑血流。此外，通过靶向代谢组学和免疫荧光分析相关神经递质和蛋白质。月橘挥发油通过上调 ERK/AKT 介导的 GLT-1 表达，显著降低 CUMS 小鼠中的 Glu，这与潜在的抗抑郁机制有关。
Psychopharmacology (Berl). 2016-9
Front Pharmacol. 2024-6-25
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