mA-mediated upregulation of lncRNA boosts the progression of bladder cancer via epigenetically suppressing .

This study aimed to elucidate the relationship between and in bladder cancer and their underlying mechanism. Biological functions were evaluated using cell-counting kit 8 assay, 5-ethynyl-2'-deoxyuridine incorporation, wound healing and Transwell assays. RNA immunoprecipitation, RNA pull-down and chromatin immunoprecipitation were employed. A xenograft tumor model in nude mice was also conducted. and exhibited an inverse correlation. Downregulation of significantly suppressed bladder cancer cell proliferation, migration and invasion, which was reversed by overexpression. recruited DNA methyltransferases to the promoter region of , thereby triggering the methylation of the promoter to epigenetically suppress its expression. Our findings elucidate the machinery by which , stabilized by METTL3, exerts a promoter role in bladder cancer tumorigenesis by triggering methylation.