肿瘤核型在人类神经母细胞瘤的预后中可能具有重要意义。
Tumour karyotype may be important in the prognosis of human neuroblastoma.
作者信息
Franke F, Rudolph B, Christiansen H, Harbott J, Lampert F
出版信息
J Cancer Res Clin Oncol. 1986;111(3):266-72. doi: 10.1007/BF00389243.
Abstract
When comparing clinical and tumour cytogenetic data on 14 neuroblastoma patients in different stages of disease we found a high incidence of 1p abnormalities (12/12), homogeneously staining regions/double minutes (9/12) and 2p abnormalities (4/12) in 12 unresectable and metastatic tumours (clinical stages III and IV). In contrast, these features were absent in clinical stage II tumours (2/2) with good prognosis. The coincidence of 1p aberrations with poor outcome of disease will be discussed.
摘要
在比较14例处于不同疾病阶段的神经母细胞瘤患者的临床和肿瘤细胞遗传学数据时，我们发现在12例无法切除的转移性肿瘤（临床III期和IV期）中，1p异常（12/12）、均匀染色区/双微体（9/12）和2p异常（4/12）的发生率很高。相比之下，预后良好的临床II期肿瘤（2/2）中不存在这些特征。将讨论1p畸变与疾病不良预后的相关性。
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