Lee Youngseop, Zhang Hao F, Sun Cheng
Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Department of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Nano Converg. 2023 Jun 20;10(1):30. doi: 10.1186/s40580-023-00378-2.
Photoacoustic (PA) imaging enables noninvasive volumetric imaging of biological tissues by capturing the endogenous optical absorption contrast. Conventional ultrasound detectors using piezoelectric materials have been widely used for transducing ultrasound signals into the electrical signals for PA imaging reconstruction. However, their inherent limitations in detection bandwidth and sensitivity per unit area have unfortunately constrained the performance of PA imaging. Optical based ultrasound detection methods emerge to offer very promising solutions. In particular, polymer micro-ring resonators (MRRs) in the form of integrated photonic circuits (IPC) enable significant reduction for the sensing area to 80 μm in diameter, while maintaining highly sensitive ultrasound detection with noise equivalent pressure (NEP) of 0.49 Pa and a broad detection frequency range up to 250 MHz. The continued engineering innovation has further transformed MRRs to be transparent to the light and thus, opens up a wide range of applications, including multi-modality optical microscope with isometric resolution, PA endoscope, photoacoustic computed tomography (PACT), and more. This review article summarizes and discusses the evolution of polymer MRR design and the associated nanofabrication process for improving the performance of ultrasound detection. The resulting novel imaging applications will also be reviewed and discussed.
光声(PA)成像通过捕捉内源性光吸收对比度,实现对生物组织的无创体积成像。使用压电材料的传统超声探测器已被广泛用于将超声信号转换为电信号,以进行光声成像重建。然而,它们在检测带宽和单位面积灵敏度方面的固有局限性,不幸地限制了光声成像的性能。基于光学的超声检测方法应运而生,提供了非常有前景的解决方案。特别是,集成光子电路(IPC)形式的聚合物微环谐振器(MRR)能够将传感面积显著减小至直径80μm,同时保持高灵敏度的超声检测,噪声等效压力(NEP)为0.49Pa,检测频率范围高达250MHz。持续的工程创新进一步使MRR对光透明,从而开辟了广泛的应用领域,包括具有等距分辨率的多模态光学显微镜、光声内窥镜、光声计算机断层扫描(PACT)等等。本文综述并讨论了聚合物MRR设计的演变以及相关的纳米制造工艺,以提高超声检测性能。由此产生的新型成像应用也将得到综述和讨论。