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澳大利亚一项多中心、横断面、观察性研究:骨科手术前阿片类药物使用的流行情况和预测因素。

Prevalence and predictors of opioid use before orthopaedic surgery in an Australian setting: A multicentre, cross-sectional, observational study.

机构信息

Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Department of Pharmacy, Prince of Wales Hospital, Randwick, Australia.

出版信息

Anaesth Intensive Care. 2023 Sep;51(5):331-339. doi: 10.1177/0310057X221147066. Epub 2023 Jun 20.

Abstract

Opioid analgesics are commonly used by patients awaiting orthopaedic surgery, and preoperative opioid use is associated with a greater burden of postoperative pain, suboptimal surgical outcomes and higher healthcare costs. This study aimed to examine the prevalence of total opioid use before elective orthopaedic surgery with a focus on regional and rural hospitals in New South Wales, Australia. This was a cross-sectional, observational study of patients undergoing orthopaedic surgery conducted between April 2017 and November 2019 across five hospitals that included a mix of metropolitan, regional, rural, private and public settings. Preoperative patient demographics, pain scores and analgesic use were collected during pre-admission clinic visits, held between two and six weeks before surgery. Of the 430 patients included, 229 (53.3%) were women and the mean age was 67.5 (standard deviation 10.1) years. The overall prevalence of total preoperative opioid use was 37.7% (162/430). Rates of preoperative opioid use ranged from 20.6% (13/63) at a metropolitan hospital to 48.8% (21/43) at an inner regional hospital. Multivariable logistic regression showed that the inner regional setting was a significant predictor of opioid use before orthopaedic surgery (adjusted odds ratio 2.6; 95% confidence interval 1.0 to 6.7) after adjusting for covariates. Opioid use prior to orthopaedic surgery is common and appears to vary by geographical location.

摘要

阿片类镇痛药在等待矫形外科手术的患者中常用,术前使用阿片类药物与术后疼痛负担更大、手术效果不理想和医疗保健费用增加有关。本研究旨在检查澳大利亚新南威尔士州择期矫形外科手术前总阿片类药物使用的流行情况,重点是区域和农村医院。这是一项在 2017 年 4 月至 2019 年 11 月期间在五家医院进行的骨科手术患者的横断面、观察性研究,这些医院包括大都市、区域、农村、私立和公立医院。在手术前两周至六周期间在术前就诊期间收集了术前患者的人口统计学、疼痛评分和镇痛药使用情况。在纳入的 430 名患者中,有 229 名(53.3%)为女性,平均年龄为 67.5(标准差 10.1)岁。总术前阿片类药物使用的总体流行率为 37.7%(162/430)。术前阿片类药物使用的发生率从大都市医院的 20.6%(13/63)到内部区域医院的 48.8%(21/43)不等。多变量逻辑回归显示,内部区域环境是骨科手术前使用阿片类药物的一个重要预测因素(调整后的优势比 2.6;95%置信区间 1.0 至 6.7),在调整协变量后。术前使用阿片类药物在矫形外科手术中很常见,而且似乎因地理位置而异。

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