Continuum (Minneap Minn). 2023 Jun 1;29(3):826-847. doi: 10.1212/CON.0000000000001238.
This article discusses the epidemiology, diagnosis, treatment, and prevention of neurologic complications of red blood cell, platelet, and plasma cell disorders.
Cerebrovascular complications can occur in patients with blood cell and platelet disorders. Treatment strategies to prevent stroke are available for patients with sickle cell disease, polycythemia vera, and essential thrombocythemia. A diagnosis of thrombotic thrombocytopenic purpura should be considered in patients with neurologic symptoms, hemolytic anemia, thrombocytopenia, mild renal insufficiency, and fever. Plasma cell disorders can be associated with peripheral neuropathy, and classification of the monoclonal protein type and neuropathy aid in diagnosis. Patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes) syndrome can present with arterial and venous neurologic events.
This article discusses the neurologic complications of blood cell disorders and the most recent advances in prevention and treatment.
本文讨论了红细胞、血小板和浆细胞疾病的神经并发症的流行病学、诊断、治疗和预防。
血细胞和血小板疾病患者可发生脑血管并发症。针对镰状细胞病、真性红细胞增多症和特发性血小板增多症患者，已有预防中风的治疗策略。有神经症状、溶血性贫血、血小板减少、轻度肾功能不全和发热的患者，应考虑血栓性血小板减少性紫癜的诊断。浆细胞疾病可伴有周围神经病，单克隆蛋白类型和神经病的分类有助于诊断。POEMS（多发性神经病、器官肿大、内分泌病、单克隆浆细胞病和皮肤改变）综合征患者可出现动脉和静脉性神经系统事件。
本文讨论了血细胞疾病的神经并发症以及预防和治疗的最新进展。
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