PCR 检测未能准确预测金黄色葡萄球菌感染性心内膜炎患者对苯唑西林的耐药性。
Failure of PCR Testing to Accurately Predict Oxacillin Resistance in a Patient with Staphylococcus aureus Infective Endocarditis.
机构信息
Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
出版信息
Antimicrob Agents Chemother. 2023 Oct;67(10):e0043723. doi: 10.1128/aac.00437-23. Epub 2023 Jun 21.
Abstract
Genotypic testing for / is heavily relied upon for rapid optimization of antimicrobial therapy in infections due to Staphylococcus aureus. Little is known regarding optimal reporting and/or therapy for patients demonstrating lack of genotypic evidence of or but phenotypic oxacillin resistance. We report a case of a 77-year-old patient with S. aureus bloodstream infection and infective endocarditis with discordance between genotypic results and phenotypic susceptibility testing.
摘要
基因检测在金黄色葡萄球菌感染的抗菌治疗快速优化中起着重要作用。对于缺乏 或 基因型证据但表现出表型耐苯唑西林的患者，其最佳报告和/或治疗方法知之甚少。我们报告了一例 77 岁患者的金黄色葡萄球菌血流感染和感染性心内膜炎病例，基因型结果与表型药敏试验之间存在差异。
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