School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom.
Bioorg Med Chem. 2023 Jul 15;90:117372. doi: 10.1016/j.bmc.2023.117372. Epub 2023 Jun 12.
Research into the human microbiome has implicated its constituents in a variety of non-communicable diseases, with certain microbes found to promote health and others leading to dysbiosis and pathogenesis.Microbes communicate and coordinate their behaviour through the secretion of small molecules, such as cyclic dipeptides (CDPs), into their surrounding environment. CDPs are ubiquitous signalling molecules thatexhibit a wide range of biological activities, with particular relevance to human health due to their potential to act as microbiome modulators.
人类微生物组的研究表明，其组成部分与多种非传染性疾病有关，某些微生物有助于促进健康，而其他微生物则导致微生态失调和发病机制。微生物通过向周围环境分泌小分子（如环二肽（CDP））来进行交流和协调其行为。CDP 是普遍存在的信号分子，具有广泛的生物学活性，由于它们具有作为微生物组调节剂的潜力，因此与人类健康特别相关。
