SUMF1 多态性与 COVID-19 严重程度的关联。
Association between SUMF1 polymorphisms and COVID-19 severity.
机构信息
Department of Respiratory, Hebei Chest Hospital, Shijiazhuang, 050000, Hebei, China.
Department of Laboratory Medicine, The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, 050021, Hebei, China.
出版信息
BMC Genom Data. 2023 Jun 21;24(1):34. doi: 10.1186/s12863-023-01133-6.
BACKGROUND
Evidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory response. Therefore, we speculate that it may play a key role in COVID-19.
RESULTS
We found that rs794185 was significantly associated with COVID-19 severity in Chinese population, under the additive model after adjusting for gender and age (for C allele = 0.62, 95% CI = 0.44-0.88, P = 0.0073, logistic regression). And this association was consistent with this in European population Genetics Of Mortality In Critical Care (GenOMICC: OR for C allele = 0.94, 95% CI = 0.90-0.98, P = 0.0037). Additionally, we also revealed a remarkable association between rs794185 and the prothrombin activity (PTA) in subjects (P = 0.015, Generalized Linear Model).
CONCLUSIONS
In conclusion, our study for the first time identified that rs794185 in SUMF1 gene was associated with the severity of COVID-19.
背景
有证据表明，遗传因素在 2019 年冠状病毒病（COVID-19）的严重程度中起重要作用。硫酸酯酶修饰因子 1（SUMF1）基因参与肺泡损伤和全身炎症反应。因此，我们推测它可能在 COVID-19 中起关键作用。
结果
我们发现 rs794185 在调整性别和年龄后，在加性模型下与中国人群 COVID-19 的严重程度显著相关（对于 C 等位基因= 0.62，95%CI = 0.44-0.88，P = 0.0073，逻辑回归）。这种关联与欧洲人群遗传学在重症监护中的死亡率（GenOMICC：对于 C 等位基因= 0.94，95%CI = 0.90-0.98，P = 0.0037）的关联一致。此外，我们还在研究对象中发现 rs794185 与凝血酶原活性（PTA）之间存在显著关联（P = 0.015，广义线性模型）。
结论
总之，我们的研究首次发现 SUMF1 基因中的 rs794185 与 COVID-19 的严重程度有关。
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