Department of Physical Therapy, University of AL at Birmingham, Birmingham, AL, USA.
American Sports Medicine Institute, Birmingham, AL, USA.
Disabil Rehabil. 2024 Jun;46(12):2522-2527. doi: 10.1080/09638288.2023.2225876. Epub 2023 Jun 22.
This study examined the bivariate association between fatigue and depression symptoms and physical activity behavior in persons with multiple sclerosis (MS).
The sample of adults with MS completed the Fatigue Severity Scale (FSS) and the Hospital Anxiety and Depression Scale (HADS) and wore a waist mounted accelerometer during waking hours for 7 days. We categorized participants as having elevated fatigue and depression based on cut-points for the FSS (i.e., 4+ as indicative of severe fatigue) and the HADS (i.e., 8+ as indicative of elevated depressive symptoms). We used a two-way multivariate analysis of variance (MANOVA) to examine the contribution of fatigue and depression to volume and pattern of sedentary, light (LPA) and moderate-to-vigorous physical activity (MVPA).
Results indicated no bivariate association between fatigue and depression and measures of physical activity behavior. The MANOVA indicated there was a significant association between fatigue and MVPA ( = 2.30, = 0.032) and steps/day ( = 13.6, < 0.001), independent of depression symptoms. There was no association between depression symptoms and physical activity behavior.
This study demonstrated an interrelation between fatigue symptoms and MVPA and steps/day in MS, independent of depression symptoms, and this should be considered in the future design and delivery of physical activity interventions in MS.IMPLICATIONS FOR REHABILIATIONFatigue and depression are prevalent and burdensome symptoms of multiple sclerosis (MS).These symptoms can collectively worsen psychological and functional outcomes in MS.Fatigue symptoms may impact ambulatory physical activity to a greater degree than depression symptom status in persons with MS.Fatigue is an important consideration when designing behavior change interventions targeted at promoting physical activity in persons with MS.
本研究考察了多发性硬化症（MS）患者疲劳和抑郁症状与身体活动行为之间的二元关联。
该成年人 MS 样本完成了疲劳严重程度量表（FSS）和医院焦虑抑郁量表（HADS），并在清醒时佩戴腰部安装的加速度计 7 天。我们根据 FSS 的切点（即 4+表示严重疲劳）和 HADS（即 8+表示升高的抑郁症状）将参与者分为疲劳和抑郁升高。我们使用双向多元方差分析（MANOVA）来检查疲劳和抑郁对久坐、轻度（LPA）和中等到剧烈体力活动（MVPA）的量和模式的贡献。
结果表明，疲劳和抑郁与身体活动行为的测量之间没有二元关联。MANOVA 表明，疲劳与 MVPA（ = 2.30， = 0.032）和步数/天（ = 13.6， < 0.001）之间存在显著关联，与抑郁症状无关。抑郁症状与身体活动行为之间没有关联。
本研究表明，MS 中疲劳症状与 MVPA 和步数/天之间存在相互关系，与抑郁症状无关，这在未来 MS 中设计和实施身体活动干预措施时应加以考虑。
疲劳和抑郁是多发性硬化症（MS）的常见且负担沉重的症状。这些症状可能共同导致 MS 患者的心理和功能结局恶化。疲劳症状可能比抑郁症状更能影响多发性硬化症患者的日常身体活动。在设计针对多发性硬化症患者促进身体活动的行为改变干预措施时，疲劳是一个重要的考虑因素。
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