Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Center of Clinical Research and Quality Management, University of the Ryukyus Hospital, Nishihara, Okinawa, Japan.
PLoS One. 2023 Jun 23;18(6):e0283417. doi: 10.1371/journal.pone.0283417. eCollection 2023.
Despite the broad global use of antibiotics, there is no established definition of early antibiotic treatment failure (EATF) to aid clinical evaluation of treatment, which leads to inconsistent assessments of drug effectiveness.
This scoping review aims to identify common components of EATF definitions by synthesizing studies mentioning EATF and its relevant thesaurus matches.
Scoping review.
This scoping review was conducted following the PRISMA Scoping review guidelines. A systematic literature search was conducted using MEDLINE (PubMed), CENTRAL, CINAHL, and Web of Science, as well as a manual Google search. Search terms were EATF and its thesaurus matches. After removing duplications, candidate studies were screened by title and abstract prior to full text searches, and quality analysis was performed on eligible studies using the Critical Appraisal Skills Programme. From each eligible study, the timing of evaluation, basic components, and detailed information for each definition of EATF were collected. The components of each definition for EATF were then summarized and counted, and finally the most common essential components were identified.
Our systematic literature search found 2,472 candidate studies. After title and abstract screening, full text search and quality assessment, 61 studies, including 56 original studies and five reviews, were eligible for our analysis. Of these 56 original studies, 43 mentioned the timing of EATF evaluation 72 hours after the start of treatment with antibiotics. From these 43 studies, the most common indicators of EATF were extracted, among which a set of essential components for a definition of EATF were identified: mortality, vital signs, fever, symptoms, and additional treatment.
Our scoping review uncovered five essential factors for EATF. Further study is needed to evaluate the validity of our findings.
尽管抗生素在全球范围内广泛使用，但目前尚无确定的早期抗生素治疗失败 (EATF) 定义来帮助临床评估治疗效果，这导致对药物疗效的评估不一致。
本范围综述旨在通过综合提及 EATF 及其相关词表匹配的研究，确定 EATF 定义的常见组成部分。
范围综述。
本范围综述按照 PRISMA 范围综述指南进行。使用 MEDLINE（PubMed）、CENTRAL、CINAHL 和 Web of Science 进行系统文献检索，并进行了手动 Google 搜索。检索词为 EATF 和其词表匹配。在进行全文搜索之前，先去除重复项，通过标题和摘要筛选候选研究，并使用关键评估技能计划对合格研究进行质量分析。从每项合格研究中，收集 EATF 评估时间、基本组成部分和每个 EATF 定义的详细信息。然后总结和计数每个 EATF 定义的组成部分，并最终确定最常见的基本组成部分。
我们的系统文献检索发现了 2472 项候选研究。经过标题和摘要筛选、全文搜索和质量评估，有 61 项研究符合我们的分析标准，包括 56 项原始研究和 5 项综述。在这 56 项原始研究中，有 43 项提到了 EATF 评估的时间，即在开始使用抗生素治疗后 72 小时。从这 43 项研究中，提取了 EATF 的最常见指标，其中确定了 EATF 定义的一组基本组成部分：死亡率、生命体征、发热、症状和额外治疗。
我们的范围综述发现了 EATF 的五个基本要素。需要进一步研究来评估我们研究结果的有效性。
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