Lake Erie College of Osteopathic Medicine at Seton Hill, Department of Microbiology, Greensburg, USA.
University of Maryland Medical Center/Sheppard Pratt Psychiatry Residency Program, Baltimore, USA.
Transl Psychiatry. 2023 Jun 23;13(1):221. doi: 10.1038/s41398-023-02483-6.
Bipolar affective disorder (BPAD) are life-long disorders that account for significant morbidity in afflicted patients. The etiology of BPAD is complex, combining genetic and environmental factors to increase the risk of disease. Genetic studies have pointed toward cytoskeletal dysfunction as a potential molecular mechanism through which BPAD may arise and have implicated proteins that regulate the cytoskeleton as risk factors. Microtubule actin crosslinking factor 1 (MACF1) is a giant cytoskeletal crosslinking protein that can coordinate the different aspects of the mammalian cytoskeleton with a wide variety of actions. In this review, we seek to highlight the functions of MACF1 in the nervous system and the molecular mechanisms leading to BPAD pathogenesis. We also offer a brief perspective on MACF1 and the role it may be playing in lithium's mechanism of action in treating BPAD.
双相情感障碍（BPAD）是一种终身性疾病，会给患者带来严重的身体和精神负担。BPAD 的病因非常复杂，涉及遗传和环境等多种因素。遗传研究表明细胞骨架功能障碍可能是 BPAD 的潜在发病机制之一，调节细胞骨架的蛋白也可能是其风险因素。微管肌动蛋白交联因子 1（MACF1）是一种巨大的细胞骨架交联蛋白，能够通过多种作用协调哺乳动物细胞骨架的不同方面。本综述旨在强调 MACF1 在神经系统中的功能及其导致 BPAD 发病机制的分子机制。我们还简要探讨了 MACF1 及其在锂治疗 BPAD 中的作用机制。
