[组织型纤溶酶原激活剂在肿瘤疾病诊断中的辅助价值]
[Auxiliary value of TPA in diagnosing neoplastic diseases].
作者信息
Mizushima Y, Nakamura F, Yokoyama A, Morikage T, Kawasaki S, Hoshino K, Maruyama M, Yamashita N, Yano S
出版信息
Gan No Rinsho. 1986 Jun;32(7):779-82.
The auxiliary value of TPA in diagnosing neoplastic diseases was compared to other tumor markers such as CEA, IAP and ferritin. The study population consisted of 59 patients with neoplastic diseases and 75 with benign diseases. The percentages of positive cases for TPA, CEA, IPA and ferritin were 58.9%, 39.0%, 66.7%, and 28.6% in neoplastic diseases and 4.5%, 1.4%, 47.1% and 19.7% in benign diseases, respectively. Both the specificity and sensitivity of TPA were as high as those of CEA. However, the positive rate of TPA was lower than that of CEA in lung cancer patients at stages I and II. TPA was indicated to be a suitable marker for combination assay with CEA in diagnosing neoplastic diseases.
将组织多肽抗原（TPA）在诊断肿瘤性疾病中的辅助价值与其他肿瘤标志物如癌胚抗原（CEA）、免疫抑制酸性蛋白（IAP）和铁蛋白进行了比较。研究人群包括59例肿瘤性疾病患者和75例良性疾病患者。肿瘤性疾病中TPA、CEA、IAP和铁蛋白的阳性病例百分比分别为58.9%、39.0%、66.7%和28.6%，良性疾病中分别为4.5%、1.4%、47.1%和19.7%。TPA的特异性和敏感性与CEA一样高。然而，在Ⅰ期和Ⅱ期肺癌患者中，TPA的阳性率低于CEA。TPA被认为是与CEA联合检测诊断肿瘤性疾病的合适标志物。
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