Research has shown that minority stress is linked to poorer mental health across a variety of stigmatized populations, including lesbian, gay, bisexual, and queer (LGBQ) people. It is therefore essential to understand factors that can counteract minority stress. To date, most research on LGBQ people's resilience relied on retrospective reports of stressful identity-salient experiences. This limits the understanding about resilience factors that enable LGBQ people to thrive in the face of minority stressors as they occur on a day-to-day basis. The present study addressed this gap by using a daily diary design to test whether self-compassion protects LGBQ people's affective well-being from daily stressful sexual orientation-salient experiences (SOSEs). A sample of 235 LGBQ adults completed a baseline survey that assessed self-compassion, as well as brief online surveys twice daily for a maximum of 17 days that assessed SOSEs and affect, providing a total of 3,310 days of data. As anticipated, results of multilevel modeling showed that negative and positive SOSEs were linked to negative and positive evening affect, respectively, at both the daily and person levels. Self-compassion moderated the link between daily negative SOSEs and positive evening affect, such that daily negative SOSEs were linked to lower positive affect only among those with lower self-compassion. Moderation effect was not observed for negative evening affect as an outcome. Exploratory analysis suggested that the buffering effect of self-compassion could be impacted by contextual factors. Our study showed the importance of self-compassion and access to positive SOSEs for LGBQ people's well-being. (PsycInfo Database Record (c) 2023 APA, all rights reserved).